<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019c9f94-7e70-7e0e-a6c2-a24631d5da97,g:457a992b-845c-4566-8a22-6951525463e3-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.busey.com/role/CONSOLIDATEDBALANCESHEETSUnaudited" xlink:type="simple" xlink:href="buse-20260331.xsd#CONSOLIDATEDBALANCESHEETSUnaudited"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/CONSOLIDATEDBALANCESHEETSUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_019c9f94-8456-7262-9f0c-d48207356412" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Deposits"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestBearingDepositLiabilities_019c9f94-8456-7d4e-9401-b2417e7556e1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestBearingDepositLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_019c9f94-8456-7262-9f0c-d48207356412" xlink:to="loc_us-gaap_NoninterestBearingDepositLiabilities_019c9f94-8456-7d4e-9401-b2417e7556e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestBearingDepositLiabilities_019c9f94-8456-7a94-a2d5-3da3de98d81a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestBearingDepositLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_019c9f94-8456-7262-9f0c-d48207356412" xlink:to="loc_us-gaap_InterestBearingDepositLiabilities_019c9f94-8456-7a94-a2d5-3da3de98d81a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019c9f94-8456-7870-bd19-d0594983dfdf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_019c9f94-8456-74ab-b154-33411be7c2bb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Deposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019c9f94-8456-7870-bd19-d0594983dfdf" xlink:to="loc_us-gaap_Deposits_019c9f94-8456-74ab-b154-33411be7c2bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_019c9f94-8456-7223-81a9-5669bce07793" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019c9f94-8456-7870-bd19-d0594983dfdf" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_019c9f94-8456-7223-81a9-5669bce07793" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubordinatedDebt_019c9f94-8456-7fe9-8b0e-1b8d9ecd351a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubordinatedDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019c9f94-8456-7870-bd19-d0594983dfdf" xlink:to="loc_us-gaap_SubordinatedDebt_019c9f94-8456-7fe9-8b0e-1b8d9ecd351a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLongTermDebt_019c9f94-8456-7bee-8741-fc271be20ec7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLongTermDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019c9f94-8456-7870-bd19-d0594983dfdf" xlink:to="loc_us-gaap_OtherLongTermDebt_019c9f94-8456-7bee-8741-fc271be20ec7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_JuniorSubordinatedDebentureOwedToUnconsolidatedSubsidiaryTrust_019c9f94-8456-7e0f-b117-7415101851a6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_JuniorSubordinatedDebentureOwedToUnconsolidatedSubsidiaryTrust"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019c9f94-8456-7870-bd19-d0594983dfdf" xlink:to="loc_us-gaap_JuniorSubordinatedDebentureOwedToUnconsolidatedSubsidiaryTrust_019c9f94-8456-7e0f-b117-7415101851a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilities_019c9f94-8456-7e6d-a8c1-a231063f1b57" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019c9f94-8456-7870-bd19-d0594983dfdf" xlink:to="loc_us-gaap_OtherLiabilities_019c9f94-8456-7e6d-a8c1-a231063f1b57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherShortTermBorrowings_019daa45-2fd3-75a7-a052-84569128a7d0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherShortTermBorrowings"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019c9f94-8456-7870-bd19-d0594983dfdf" xlink:to="loc_us-gaap_OtherShortTermBorrowings_019daa45-2fd3-75a7-a052-84569128a7d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019c9f94-8456-7ce2-911e-0429822f8d47" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestBearingDepositsInBanks_019c9f94-8456-7d43-91d7-dab5a20039ab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestBearingDepositsInBanks"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019c9f94-8456-7ce2-911e-0429822f8d47" xlink:to="loc_us-gaap_InterestBearingDepositsInBanks_019c9f94-8456-7d43-91d7-dab5a20039ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndDueFromBanks_019c9f94-8456-7c02-a1ac-9905def16050" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndDueFromBanks"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019c9f94-8456-7ce2-911e-0429822f8d47" xlink:to="loc_us-gaap_CashAndDueFromBanks_019c9f94-8456-7c02-a1ac-9905def16050" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityBeforeTreasuryStock_019c9f94-8456-7711-88f7-15c9aa557585" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquityBeforeTreasuryStock"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019c9f94-8456-7ffb-92cc-e6d2ff2a7b20" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityBeforeTreasuryStock_019c9f94-8456-7711-88f7-15c9aa557585" xlink:to="loc_us-gaap_CommonStockValue_019c9f94-8456-7ffb-92cc-e6d2ff2a7b20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_019c9f94-8456-7534-b135-f7253e712f20" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityBeforeTreasuryStock_019c9f94-8456-7711-88f7-15c9aa557585" xlink:to="loc_us-gaap_AdditionalPaidInCapital_019c9f94-8456-7534-b135-f7253e712f20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019c9f94-8456-76c2-bc99-d56398309e2b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityBeforeTreasuryStock_019c9f94-8456-7711-88f7-15c9aa557585" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019c9f94-8456-76c2-bc99-d56398309e2b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019c9f94-8456-76ac-be5f-0e99f017bf5a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityBeforeTreasuryStock_019c9f94-8456-7711-88f7-15c9aa557585" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019c9f94-8456-76ac-be5f-0e99f017bf5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_019c9f94-8456-7435-abc8-7352fcdadb8f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityBeforeTreasuryStock_019c9f94-8456-7711-88f7-15c9aa557585" xlink:to="loc_us-gaap_PreferredStockValue_019c9f94-8456-7435-abc8-7352fcdadb8f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019c9f94-8456-7467-9833-7e5cc8320a96" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityBeforeTreasuryStock_019c9f94-8456-7ed3-85a5-b6e001ddb12f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquityBeforeTreasuryStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019c9f94-8456-7467-9833-7e5cc8320a96" xlink:to="loc_us-gaap_StockholdersEquityBeforeTreasuryStock_019c9f94-8456-7ed3-85a5-b6e001ddb12f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_019c9f94-8456-7b82-a772-a95e30628c20" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019c9f94-8456-7467-9833-7e5cc8320a96" xlink:to="loc_us-gaap_TreasuryStockValue_019c9f94-8456-7b82-a772-a95e30628c20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019c9f94-8456-7a63-bdf9-68c80341969c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019c9f94-8456-7d7a-8dc7-0452fca7f4cf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c9f94-8456-7a63-bdf9-68c80341969c" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019c9f94-8456-7d7a-8dc7-0452fca7f4cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019c9f94-8456-7e57-8a3c-5b48c8f4283f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c9f94-8456-7a63-bdf9-68c80341969c" xlink:to="loc_us-gaap_Goodwill_019c9f94-8456-7e57-8a3c-5b48c8f4283f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_019c9f94-8456-79e5-91ac-9cfd80b3b322" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c9f94-8456-7a63-bdf9-68c80341969c" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_019c9f94-8456-79e5-91ac-9cfd80b3b322" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019c9f94-8456-7b6f-890b-7d7029d2ecdc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c9f94-8456-7a63-bdf9-68c80341969c" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019c9f94-8456-7b6f-890b-7d7029d2ecdc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssets_019c9f94-8456-7177-8c0b-d480acdc3776" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c9f94-8456-7a63-bdf9-68c80341969c" xlink:to="loc_us-gaap_OtherAssets_019c9f94-8456-7177-8c0b-d480acdc3776" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_019c9f94-8456-705e-8e2f-97ea0b89f3c6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c9f94-8456-7a63-bdf9-68c80341969c" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_019c9f94-8456-705e-8e2f-97ea0b89f3c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankStockAndFederalReserveBankStock_019c9f94-8456-7e25-ad31-01183603458f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FederalHomeLoanBankStockAndFederalReserveBankStock"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c9f94-8456-7a63-bdf9-68c80341969c" xlink:to="loc_us-gaap_FederalHomeLoanBankStockAndFederalReserveBankStock_019c9f94-8456-7e25-ad31-01183603458f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_019c9f94-8456-7d16-a96e-67365bb6d4ee" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c9f94-8456-7a63-bdf9-68c80341969c" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_019c9f94-8456-7d16-a96e-67365bb6d4ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8456-7da8-8d02-871f3947d735" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c9f94-8456-7a63-bdf9-68c80341969c" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8456-7da8-8d02-871f3947d735" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroup_019c9f94-8456-7e61-838b-241bc4406c07" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroup"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c9f94-8456-7a63-bdf9-68c80341969c" xlink:to="loc_us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroup_019c9f94-8456-7e61-838b-241bc4406c07" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashSurrenderValueOfLifeInsurance_019c9f94-8456-7177-a444-7cc85999b381" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashSurrenderValueOfLifeInsurance"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c9f94-8456-7a63-bdf9-68c80341969c" xlink:to="loc_us-gaap_CashSurrenderValueOfLifeInsurance_019c9f94-8456-7177-a444-7cc85999b381" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019c9f94-8456-7a3b-8725-bdbf2cf401b2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c9f94-8456-7a63-bdf9-68c80341969c" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019c9f94-8456-7a3b-8725-bdbf2cf401b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_InterestBearingDepositsInBanksAndOtherFinancialInstitutionsOther_019dd1d3-6e3a-73d7-9cfc-e6612276bb66" xlink:href="buse-20260331.xsd#buse_InterestBearingDepositsInBanksAndOtherFinancialInstitutionsOther"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c9f94-8456-7a63-bdf9-68c80341969c" xlink:to="loc_buse_InterestBearingDepositsInBanksAndOtherFinancialInstitutionsOther_019dd1d3-6e3a-73d7-9cfc-e6612276bb66" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019c9f94-8456-7ae2-b3d4-8e77ca9bb7b6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019c9f94-8456-7dfa-bb76-ef7c74fa8261" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019c9f94-8456-7ae2-b3d4-8e77ca9bb7b6" xlink:to="loc_us-gaap_Liabilities_019c9f94-8456-7dfa-bb76-ef7c74fa8261" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019c9f94-8456-720d-900d-2a7175f1382e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019c9f94-8456-7ae2-b3d4-8e77ca9bb7b6" xlink:to="loc_us-gaap_StockholdersEquity_019c9f94-8456-720d-900d-2a7175f1382e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019c9f94-8456-7c60-b83b-c0bb7ad62e60" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019c9f94-8456-7ae2-b3d4-8e77ca9bb7b6" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019c9f94-8456-7c60-b83b-c0bb7ad62e60" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/CONSOLIDATEDSTATEMENTSOFINCOMEUnaudited" xlink:type="simple" xlink:href="buse-20260331.xsd#CONSOLIDATEDSTATEMENTSOFINCOMEUnaudited"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/CONSOLIDATEDSTATEMENTSOFINCOMEUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_019c9f94-8505-746f-a5db-52568fada6b8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_019c9f94-8505-765c-8d1c-89b2aa630e30" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_019c9f94-8505-746f-a5db-52568fada6b8" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_019c9f94-8505-765c-8d1c-89b2aa630e30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfMortgageLoans_019c9f94-8505-79bc-b9a9-c018ee32cefa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GainLossOnSaleOfMortgageLoans"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_019c9f94-8505-746f-a5db-52568fada6b8" xlink:to="loc_us-gaap_GainLossOnSaleOfMortgageLoans_019c9f94-8505-79bc-b9a9-c018ee32cefa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankOwnedLifeInsuranceIncome_019c9f94-8505-7875-822b-d189755e42ea" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BankOwnedLifeInsuranceIncome"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_019c9f94-8505-746f-a5db-52568fada6b8" xlink:to="loc_us-gaap_BankOwnedLifeInsuranceIncome_019c9f94-8505-7875-822b-d189755e42ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtAndEquitySecuritiesRealizedGainLoss_019c9f94-8505-78e2-b90c-3bf886e79f45" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtAndEquitySecuritiesRealizedGainLoss"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_019c9f94-8505-746f-a5db-52568fada6b8" xlink:to="loc_us-gaap_DebtAndEquitySecuritiesRealizedGainLoss_019c9f94-8505-78e2-b90c-3bf886e79f45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_019c9f94-8505-7a4f-9f18-ef505ac707e3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_019c9f94-8505-746f-a5db-52568fada6b8" xlink:to="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_019c9f94-8505-7a4f-9f18-ef505ac707e3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncomeOtherOperatingIncome_019c9f94-8505-7e1d-841d-f2107f18e109" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestIncomeOtherOperatingIncome"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_019c9f94-8505-746f-a5db-52568fada6b8" xlink:to="loc_us-gaap_NoninterestIncomeOtherOperatingIncome_019c9f94-8505-7e1d-841d-f2107f18e109" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_019c9f94-8456-7ce3-87c3-bd9b1a803719" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_019c9f94-8456-72b1-90d0-b08a0d363cf6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_019c9f94-8456-7ce3-87c3-bd9b1a803719" xlink:to="loc_us-gaap_InterestAndDividendIncomeOperating_019c9f94-8456-72b1-90d0-b08a0d363cf6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseOperating_019c9f94-8456-7e57-a3f8-c916ce530d3f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseOperating"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_019c9f94-8456-7ce3-87c3-bd9b1a803719" xlink:to="loc_us-gaap_InterestExpenseOperating_019c9f94-8456-7e57-a3f8-c916ce530d3f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019c9f94-8456-7a44-8611-310ea9e24d4b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c9f94-8456-7b71-9e37-241067d603d8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019c9f94-8456-7a44-8611-310ea9e24d4b" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c9f94-8456-7b71-9e37-241067d603d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019c9f94-8505-7cb5-974d-6f66a8ae54b6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019c9f94-8456-7a44-8611-310ea9e24d4b" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019c9f94-8505-7cb5-974d-6f66a8ae54b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_019c9f94-8505-7b13-8e86-6a6842f55e19" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndFeeIncomeLoansAndLeases_019c9f94-8505-7b7d-98ca-a5ea13f9c7b4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestAndFeeIncomeLoansAndLeases"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_019c9f94-8505-7b13-8e86-6a6842f55e19" xlink:to="loc_us-gaap_InterestAndFeeIncomeLoansAndLeases_019c9f94-8505-7b7d-98ca-a5ea13f9c7b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesTaxable_019c9f94-8505-7a71-bbfa-2d220a34d487" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeSecuritiesTaxable"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_019c9f94-8505-7b13-8e86-6a6842f55e19" xlink:to="loc_us-gaap_InterestIncomeSecuritiesTaxable_019c9f94-8505-7a71-bbfa-2d220a34d487" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeDividend_019c9f94-8505-795e-8a92-813be1f68f81" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InvestmentIncomeDividend"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_019c9f94-8505-7b13-8e86-6a6842f55e19" xlink:to="loc_us-gaap_InvestmentIncomeDividend_019c9f94-8505-795e-8a92-813be1f68f81" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesTaxExempt_019c9f94-8505-7afd-9beb-fec31c4f4649" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeSecuritiesTaxExempt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_019c9f94-8505-7b13-8e86-6a6842f55e19" xlink:to="loc_us-gaap_InterestIncomeSecuritiesTaxExempt_019c9f94-8505-7afd-9beb-fec31c4f4649" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeOther_019c9f94-8505-7159-997c-b9163939448a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeOther"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_019c9f94-8505-7b13-8e86-6a6842f55e19" xlink:to="loc_us-gaap_InterestIncomeOther_019c9f94-8505-7159-997c-b9163939448a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_019c9f94-8456-7dff-a0b7-28fdebd726c8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_019c9f94-8456-78a7-9220-e5c7f46d23e1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_019c9f94-8456-7dff-a0b7-28fdebd726c8" xlink:to="loc_us-gaap_InterestIncomeExpenseNet_019c9f94-8456-78a7-9220-e5c7f46d23e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanLossesExpensed_019c9f94-8456-797d-8f25-c6a53c539ffa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProvisionForLoanLossesExpensed"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_019c9f94-8456-7dff-a0b7-28fdebd726c8" xlink:to="loc_us-gaap_ProvisionForLoanLossesExpensed_019c9f94-8456-797d-8f25-c6a53c539ffa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c9f94-8505-7b1b-9f65-6b8d3b1014d4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_019c9f94-8505-7f65-8376-11b3a79da091" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c9f94-8505-7b1b-9f65-6b8d3b1014d4" xlink:to="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_019c9f94-8505-7f65-8376-11b3a79da091" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_019c9f94-8505-7ef3-ba4c-cc237bf88e22" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c9f94-8505-7b1b-9f65-6b8d3b1014d4" xlink:to="loc_us-gaap_NoninterestIncome_019c9f94-8505-7ef3-ba4c-cc237bf88e22" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_019c9f94-8505-7813-b86d-ec13800993ed" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c9f94-8505-7b1b-9f65-6b8d3b1014d4" xlink:to="loc_us-gaap_NoninterestExpense_019c9f94-8505-7813-b86d-ec13800993ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_019c9f94-8505-71fc-9008-b51cf3971ac4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_019c9f94-8505-76aa-9e84-cfaf01be88d5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_019c9f94-8505-71fc-9008-b51cf3971ac4" xlink:to="loc_us-gaap_LaborAndRelatedExpense_019c9f94-8505-76aa-9e84-cfaf01be88d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OccupancyNet_019c9f94-8505-73d5-a2aa-70db6ffa532d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OccupancyNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_019c9f94-8505-71fc-9008-b51cf3971ac4" xlink:to="loc_us-gaap_OccupancyNet_019c9f94-8505-73d5-a2aa-70db6ffa532d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquipmentExpense_019c9f94-8505-7b04-aa41-c49ec85a429e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquipmentExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_019c9f94-8505-71fc-9008-b51cf3971ac4" xlink:to="loc_us-gaap_EquipmentExpense_019c9f94-8505-7b04-aa41-c49ec85a429e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InformationTechnologyAndDataProcessing_019c9f94-8505-732d-a482-cc05dd39a8f5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InformationTechnologyAndDataProcessing"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_019c9f94-8505-71fc-9008-b51cf3971ac4" xlink:to="loc_us-gaap_InformationTechnologyAndDataProcessing_019c9f94-8505-732d-a482-cc05dd39a8f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfessionalFees_019c9f94-8505-78dc-96ef-b9a869d505dd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProfessionalFees"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_019c9f94-8505-71fc-9008-b51cf3971ac4" xlink:to="loc_us-gaap_ProfessionalFees_019c9f94-8505-78dc-96ef-b9a869d505dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019c9f94-8505-77cf-804f-c368201b92b8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_019c9f94-8505-71fc-9008-b51cf3971ac4" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019c9f94-8505-77cf-804f-c368201b92b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_InterchangeExpense_019c9f94-8505-7d7c-a4de-46f8823e6e9c" xlink:href="buse-20260331.xsd#buse_InterchangeExpense"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_019c9f94-8505-71fc-9008-b51cf3971ac4" xlink:to="loc_buse_InterchangeExpense_019c9f94-8505-7d7c-a4de-46f8823e6e9c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoninterestExpense_019c9f94-8505-717c-9252-6e6401f7a775" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNoninterestExpense"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_019c9f94-8505-71fc-9008-b51cf3971ac4" xlink:to="loc_us-gaap_OtherNoninterestExpense_019c9f94-8505-717c-9252-6e6401f7a775" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalDepositInsuranceCorporationPremiumExpense_019c9f94-8505-7607-bbd7-c233461f95e5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FederalDepositInsuranceCorporationPremiumExpense"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_019c9f94-8505-71fc-9008-b51cf3971ac4" xlink:to="loc_us-gaap_FederalDepositInsuranceCorporationPremiumExpense_019c9f94-8505-7607-bbd7-c233461f95e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseOperating_019c9f94-8505-79de-bd3c-f82aac6ce35f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseOperating"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDeposits_019c9f94-8505-746c-930f-0f22e584456f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseDeposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseOperating_019c9f94-8505-79de-bd3c-f82aac6ce35f" xlink:to="loc_us-gaap_InterestExpenseDeposits_019c9f94-8505-746c-930f-0f22e584456f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseSecuritiesSoldUnderAgreementsToRepurchase_019c9f94-8505-7b98-83ba-015340711999" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseSecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseOperating_019c9f94-8505-79de-bd3c-f82aac6ce35f" xlink:to="loc_us-gaap_InterestExpenseSecuritiesSoldUnderAgreementsToRepurchase_019c9f94-8505-7b98-83ba-015340711999" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseShortTermBorrowingsExcludingFederalFundsAndSecuritiesSoldUnderAgreementsToRepurchase_019c9f94-8505-7f60-a00d-9508b690840e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseShortTermBorrowingsExcludingFederalFundsAndSecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseOperating_019c9f94-8505-79de-bd3c-f82aac6ce35f" xlink:to="loc_us-gaap_InterestExpenseShortTermBorrowingsExcludingFederalFundsAndSecuritiesSoldUnderAgreementsToRepurchase_019c9f94-8505-7f60-a00d-9508b690840e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseOtherLongTermDebt_019c9f94-8505-7f87-a4d5-11147d8cdd7a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseOtherLongTermDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseOperating_019c9f94-8505-79de-bd3c-f82aac6ce35f" xlink:to="loc_us-gaap_InterestExpenseOtherLongTermDebt_019c9f94-8505-7f87-a4d5-11147d8cdd7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseSubordinatedNotesAndDebentures_019c9f94-8505-7b23-a691-0803954db1a5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseSubordinatedNotesAndDebentures"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseOperating_019c9f94-8505-79de-bd3c-f82aac6ce35f" xlink:to="loc_us-gaap_InterestExpenseSubordinatedNotesAndDebentures_019c9f94-8505-7b23-a691-0803954db1a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseJuniorSubordinatedDebentures_019c9f94-8505-7dc6-bdb6-d999985649b5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseJuniorSubordinatedDebentures"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseOperating_019c9f94-8505-79de-bd3c-f82aac6ce35f" xlink:to="loc_us-gaap_InterestExpenseJuniorSubordinatedDebentures_019c9f94-8505-7dc6-bdb6-d999985649b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019c9f94-8505-7125-a6e2-b02e78475581" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019c9f94-8505-7f2f-b44a-c13e2f805c6c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019c9f94-8505-7125-a6e2-b02e78475581" xlink:to="loc_us-gaap_NetIncomeLoss_019c9f94-8505-7f2f-b44a-c13e2f805c6c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_019c9f94-8505-761f-9f1c-fa9becb689e1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockDividendsIncomeStatementImpact"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019c9f94-8505-7125-a6e2-b02e78475581" xlink:to="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_019c9f94-8505-761f-9f1c-fa9becb689e1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUnaudited" xlink:type="simple" xlink:href="buse-20260331.xsd#CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUnaudited"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019c9f94-8505-70e9-a3b3-5558b86321f7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_019c9f94-8505-7234-b89a-340a330db790" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019c9f94-8505-70e9-a3b3-5558b86321f7" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_019c9f94-8505-7234-b89a-340a330db790" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_019c9f94-8505-7eac-8344-1ce493002423" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019c9f94-8505-70e9-a3b3-5558b86321f7" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_019c9f94-8505-7eac-8344-1ce493002423" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_019c9f94-8505-705a-affb-9874a4ff0ee9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019c9f94-8505-70e9-a3b3-5558b86321f7" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_019c9f94-8505-705a-affb-9874a4ff0ee9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OciDebtSecuritiesAvailableForSaleTransferToHeldToMaturityAdjustmentFromAociForAmortizationOfGainLossBeforeTax_019c9f94-8505-7699-8e02-03104d479fb7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OciDebtSecuritiesAvailableForSaleTransferToHeldToMaturityAdjustmentFromAociForAmortizationOfGainLossBeforeTax"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019c9f94-8505-70e9-a3b3-5558b86321f7" xlink:to="loc_us-gaap_OciDebtSecuritiesAvailableForSaleTransferToHeldToMaturityAdjustmentFromAociForAmortizationOfGainLossBeforeTax_019c9f94-8505-7699-8e02-03104d479fb7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019c9f94-8505-7768-938e-bf64a63ce454" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019c9f94-8505-7f6d-9eb2-4b02e4e47ffa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019c9f94-8505-7768-938e-bf64a63ce454" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019c9f94-8505-7f6d-9eb2-4b02e4e47ffa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_019c9f94-8505-7bc0-a7c7-e3644b8c5c30" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019c9f94-8505-7768-938e-bf64a63ce454" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_019c9f94-8505-7bc0-a7c7-e3644b8c5c30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019c9f94-8505-76bf-aaf0-d022b5e5eab5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019c9f94-8505-72bd-bf20-37c6125d8348" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019c9f94-8505-76bf-aaf0-d022b5e5eab5" xlink:to="loc_us-gaap_NetIncomeLoss_019c9f94-8505-72bd-bf20-37c6125d8348" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019c9f94-8505-700f-8e18-4e337ac95a32" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019c9f94-8505-76bf-aaf0-d022b5e5eab5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019c9f94-8505-700f-8e18-4e337ac95a32" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_019c9f94-8505-790f-b094-cc91dc4dfb06" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019c9f94-8505-7e1e-8077-cdc7f63709f6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_019c9f94-8505-790f-b094-cc91dc4dfb06" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019c9f94-8505-7e1e-8077-cdc7f63709f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationTax_019c9f94-8505-7789-b598-e5290272cda6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_019c9f94-8505-790f-b094-cc91dc4dfb06" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationTax_019c9f94-8505-7789-b598-e5290272cda6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_019c9f94-8505-7602-bfb5-0f3998656397" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_019c9f94-8505-790f-b094-cc91dc4dfb06" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_019c9f94-8505-7602-bfb5-0f3998656397" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited" xlink:type="simple" xlink:href="buse-20260331.xsd#CONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-71e5-ab84-ef087a7f1122" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_PurchasesOfInterestBearingTimeDepositsInOtherBanks_019c9f94-8505-77e2-8648-02e79f18d64e" xlink:href="buse-20260331.xsd#buse_PurchasesOfInterestBearingTimeDepositsInOtherBanks"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-71e5-ab84-ef087a7f1122" xlink:to="loc_buse_PurchasesOfInterestBearingTimeDepositsInOtherBanks_019c9f94-8505-77e2-8648-02e79f18d64e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_ProceedsFromMaturitiesOfInterestBearingTimeDepositsInOtherBanks_019c9f94-8505-7c7b-bdd9-92c628c4ea92" xlink:href="buse-20260331.xsd#buse_ProceedsFromMaturitiesOfInterestBearingTimeDepositsInOtherBanks"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-71e5-ab84-ef087a7f1122" xlink:to="loc_buse_ProceedsFromMaturitiesOfInterestBearingTimeDepositsInOtherBanks_019c9f94-8505-7c7b-bdd9-92c628c4ea92" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireEquitySecuritiesFvNi_019c9f94-8505-7c03-b78b-5c5dced19f98" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireEquitySecuritiesFvNi"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-71e5-ab84-ef087a7f1122" xlink:to="loc_us-gaap_PaymentsToAcquireEquitySecuritiesFvNi_019c9f94-8505-7c03-b78b-5c5dced19f98" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfEquitySecuritiesFvNi_019c9f94-8505-7a8a-97be-f346a53e9e3d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromSaleOfEquitySecuritiesFvNi"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-71e5-ab84-ef087a7f1122" xlink:to="loc_us-gaap_ProceedsFromSaleOfEquitySecuritiesFvNi_019c9f94-8505-7a8a-97be-f346a53e9e3d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_019c9f94-8505-7f61-982a-7ac59dbeec76" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-71e5-ab84-ef087a7f1122" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_019c9f94-8505-7f61-982a-7ac59dbeec76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_019c9f94-8505-7f44-b0ff-c68926d9de65" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-71e5-ab84-ef087a7f1122" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_019c9f94-8505-7f44-b0ff-c68926d9de65" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_019c9f94-8505-7501-a440-190d6c3e2b52" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-71e5-ab84-ef087a7f1122" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_019c9f94-8505-7501-a440-190d6c3e2b52" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities_019c9f94-8505-7762-8ea6-fb839a887a2f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-71e5-ab84-ef087a7f1122" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities_019c9f94-8505-7762-8ea6-fb839a887a2f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_PaymentsToAcquireFederalHomeLoanBankAndFederalReserveBankStock_019c9f94-8505-74a0-b0c6-bfd5cbff24e3" xlink:href="buse-20260331.xsd#buse_PaymentsToAcquireFederalHomeLoanBankAndFederalReserveBankStock"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-71e5-ab84-ef087a7f1122" xlink:to="loc_buse_PaymentsToAcquireFederalHomeLoanBankAndFederalReserveBankStock_019c9f94-8505-74a0-b0c6-bfd5cbff24e3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_ProceedsFromRedemptionOfFederalHomeLoanBankAndFederalReserveBankStock_019c9f94-8505-7615-b400-4eb72be88574" xlink:href="buse-20260331.xsd#buse_ProceedsFromRedemptionOfFederalHomeLoanBankAndFederalReserveBankStock"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-71e5-ab84-ef087a7f1122" xlink:to="loc_buse_ProceedsFromRedemptionOfFederalHomeLoanBankAndFederalReserveBankStock_019c9f94-8505-7615-b400-4eb72be88574" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_NetIncreaseDecreaseInFinancingReceivablesInvestingActivities_019c9f94-8505-7b3d-8937-31787835afc4" xlink:href="buse-20260331.xsd#buse_NetIncreaseDecreaseInFinancingReceivablesInvestingActivities"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-71e5-ab84-ef087a7f1122" xlink:to="loc_buse_NetIncreaseDecreaseInFinancingReceivablesInvestingActivities_019c9f94-8505-7b3d-8937-31787835afc4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019c9f94-8505-7d79-92dc-78717536399c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-71e5-ab84-ef087a7f1122" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019c9f94-8505-7d79-92dc-78717536399c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireLifeInsurancePolicies_019c9f94-8505-7ac3-9123-2dc7f1bdf159" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireLifeInsurancePolicies"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-71e5-ab84-ef087a7f1122" xlink:to="loc_us-gaap_PaymentsToAcquireLifeInsurancePolicies_019c9f94-8505-7ac3-9123-2dc7f1bdf159" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromLifeInsurancePolicies_019c9f94-8505-7280-877b-99e562c2b689" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromLifeInsurancePolicies"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-71e5-ab84-ef087a7f1122" xlink:to="loc_us-gaap_ProceedsFromLifeInsurancePolicies_019c9f94-8505-7280-877b-99e562c2b689" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019c9f94-8505-7f5e-80bf-e937555c65f6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-71e5-ab84-ef087a7f1122" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019c9f94-8505-7f5e-80bf-e937555c65f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_019d7302-b594-7db5-b133-9a96eb70a1fa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-71e5-ab84-ef087a7f1122" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_019d7302-b594-7db5-b133-9a96eb70a1fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_ProceedsFromSaleOfOtherRealEstateAndOtherRepossessedAssetsIncludingCashPaymentsCollectedNet_019de222-c3fd-74c3-8355-3b8c318f1852" xlink:href="buse-20260331.xsd#buse_ProceedsFromSaleOfOtherRealEstateAndOtherRepossessedAssetsIncludingCashPaymentsCollectedNet"/>
    <link:calculationArc order="17" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-71e5-ab84-ef087a7f1122" xlink:to="loc_buse_ProceedsFromSaleOfOtherRealEstateAndOtherRepossessedAssetsIncludingCashPaymentsCollectedNet_019de222-c3fd-74c3-8355-3b8c318f1852" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019c9f94-8505-7a5b-babd-3b6d9a166d52" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7cec-b3a0-27c9338cf76e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019c9f94-8505-7a5b-babd-3b6d9a166d52" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7cec-b3a0-27c9338cf76e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-7771-8869-c554645888d6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019c9f94-8505-7a5b-babd-3b6d9a166d52" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c9f94-8505-7771-8869-c554645888d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c9f94-8505-7da2-9818-feb96a508704" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019c9f94-8505-7a5b-babd-3b6d9a166d52" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c9f94-8505-7da2-9818-feb96a508704" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c9f94-8505-79fa-a8c9-aac6640ab979" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeposits_019c9f94-8505-7e39-8fe3-a760b9a4d87e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInDeposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c9f94-8505-79fa-a8c9-aac6640ab979" xlink:to="loc_us-gaap_IncreaseDecreaseInDeposits_019c9f94-8505-7e39-8fe3-a760b9a4d87e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchaseNet_019c9f94-8505-7ca0-a2a6-901c6103664e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchaseNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c9f94-8505-79fa-a8c9-aac6640ab979" xlink:to="loc_us-gaap_IncreaseDecreaseInFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchaseNet_019c9f94-8505-7ca0-a2a6-901c6103664e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromShortTermDebt_019c9f94-8505-72b6-a073-59d4c99b187e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromShortTermDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c9f94-8505-79fa-a8c9-aac6640ab979" xlink:to="loc_us-gaap_ProceedsFromShortTermDebt_019c9f94-8505-72b6-a073-59d4c99b187e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfShortTermDebt_019c9f94-8505-775c-a309-d3864f73c1b4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RepaymentsOfShortTermDebt"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c9f94-8505-79fa-a8c9-aac6640ab979" xlink:to="loc_us-gaap_RepaymentsOfShortTermDebt_019c9f94-8505-775c-a309-d3864f73c1b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromOtherDebt_019c9f94-8505-752b-99c4-7c8fa1f0c485" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromOtherDebt"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c9f94-8505-79fa-a8c9-aac6640ab979" xlink:to="loc_us-gaap_ProceedsFromOtherDebt_019c9f94-8505-752b-99c4-7c8fa1f0c485" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfOtherDebt_019c9f94-8505-771d-b896-7a3faa68ee7c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RepaymentsOfOtherDebt"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c9f94-8505-79fa-a8c9-aac6640ab979" xlink:to="loc_us-gaap_RepaymentsOfOtherDebt_019c9f94-8505-771d-b896-7a3faa68ee7c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividends_019c9f94-8505-72f0-8c16-7d47f877d666" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsOfDividends"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c9f94-8505-79fa-a8c9-aac6640ab979" xlink:to="loc_us-gaap_PaymentsOfDividends_019c9f94-8505-72f0-8c16-7d47f877d666" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019c9f94-8505-7230-a346-162a1f78f35c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c9f94-8505-79fa-a8c9-aac6640ab979" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019c9f94-8505-7230-a346-162a1f78f35c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019c9f94-8505-7cc6-8052-6b18dcf218cb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c9f94-8505-79fa-a8c9-aac6640ab979" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019c9f94-8505-7cc6-8052-6b18dcf218cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_ProceedsFromIssuanceOfTreasuryStockForEmployeeStockPurchaseProgram_019c9f94-8505-7796-9782-d9a9cf7098b6" xlink:href="buse-20260331.xsd#buse_ProceedsFromIssuanceOfTreasuryStockForEmployeeStockPurchaseProgram"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c9f94-8505-79fa-a8c9-aac6640ab979" xlink:to="loc_buse_ProceedsFromIssuanceOfTreasuryStockForEmployeeStockPurchaseProgram_019c9f94-8505-7796-9782-d9a9cf7098b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_019c9f94-8505-7e45-a54c-0f350c15e109" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c9f94-8505-79fa-a8c9-aac6640ab979" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_019c9f94-8505-7e45-a54c-0f350c15e109" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019c9f94-8505-7ace-9942-df9be6b88899" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_us-gaap_NetIncomeLoss_019c9f94-8505-7ace-9942-df9be6b88899" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestCreditLossExpenseReversal_019c9f94-8505-7cca-8861-9e92aa238599" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestCreditLossExpenseReversal"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestCreditLossExpenseReversal_019c9f94-8505-7cca-8861-9e92aa238599" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019c9f94-8505-7978-90c5-583d960bb7ec" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019c9f94-8505-7978-90c5-583d960bb7ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfMortgageServicingRightsMSRs_019c9f94-8505-7124-b004-62c1471df3be" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfMortgageServicingRightsMSRs"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_us-gaap_AmortizationOfMortgageServicingRightsMSRs_019c9f94-8505-7124-b004-62c1471df3be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019c9f94-8505-7b1d-991c-c04b78addc1c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019c9f94-8505-7b1d-991c-c04b78addc1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfDeferredLoanOriginationFeesNet_019c9f94-8505-7d00-9a57-46467e8f67cc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfDeferredLoanOriginationFeesNet"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_us-gaap_AmortizationOfDeferredLoanOriginationFeesNet_019c9f94-8505-7d00-9a57-46467e8f67cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_019c9f94-8505-74c4-b27a-f3090f346af7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_019c9f94-8505-74c4-b27a-f3090f346af7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_AccretionOfPremiumsAndDiscountsOnTimeDeposits_019c9f94-8505-7333-8e59-2280a4683185" xlink:href="buse-20260331.xsd#buse_AccretionOfPremiumsAndDiscountsOnTimeDeposits"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_buse_AccretionOfPremiumsAndDiscountsOnTimeDeposits_019c9f94-8505-7333-8e59-2280a4683185" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_AmortizationOfDiscountOnFederalHomeLoanBankAdvances_019c9f94-8505-77b4-94c7-23f9ba68893d" xlink:href="buse-20260331.xsd#buse_AmortizationOfDiscountOnFederalHomeLoanBankAdvances"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_buse_AmortizationOfDiscountOnFederalHomeLoanBankAdvances_019c9f94-8505-77b4-94c7-23f9ba68893d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_019c9f94-8505-77c1-81ff-d77410671a9e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_019c9f94-8505-77c1-81ff-d77410671a9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgageServicingRightsMSRImpairmentRecovery_019c9f94-8505-783b-ab2a-a320e1d8dcd2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_MortgageServicingRightsMSRImpairmentRecovery"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_us-gaap_MortgageServicingRightsMSRImpairmentRecovery_019c9f94-8505-783b-ab2a-a320e1d8dcd2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInEquitySecuritiesFvNi_019c9f94-8505-7e6b-93fc-9a0497fc0be0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInEquitySecuritiesFvNi"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_us-gaap_IncreaseDecreaseInEquitySecuritiesFvNi_019c9f94-8505-7e6b-93fc-9a0497fc0be0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfInvestments_019c9f94-8505-733d-ba9e-16b81a2faa6b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GainLossOnSaleOfInvestments"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_us-gaap_GainLossOnSaleOfInvestments_019c9f94-8505-733d-ba9e-16b81a2faa6b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_GainLossOnSaleOfLoansNet_019c9f94-8505-79e0-949f-0cbe2b01b579" xlink:href="buse-20260331.xsd#buse_GainLossOnSaleOfLoansNet"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_buse_GainLossOnSaleOfLoansNet_019c9f94-8505-79e0-949f-0cbe2b01b579" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_GainsLossesOnSalesOfOtherRealEstateAndOtherRepossessedAssets_019c9f94-8505-7f1a-9182-1ab4efcc88cb" xlink:href="buse-20260331.xsd#buse_GainsLossesOnSalesOfOtherRealEstateAndOtherRepossessedAssets"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_buse_GainsLossesOnSalesOfOtherRealEstateAndOtherRepossessedAssets_019c9f94-8505-7f1a-9182-1ab4efcc88cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_019c9f94-8505-7291-956d-7f0c031cb5c5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment"/>
    <link:calculationArc order="16" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_019c9f94-8505-7291-956d-7f0c031cb5c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_GainLossOnLifeInsuranceProceeds_019c9f94-8505-7963-a41e-7440e7410bb5" xlink:href="buse-20260331.xsd#buse_GainLossOnLifeInsuranceProceeds"/>
    <link:calculationArc order="17" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_buse_GainLossOnLifeInsuranceProceeds_019c9f94-8505-7963-a41e-7440e7410bb5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LifeInsuranceCorporateOrBankOwnedChangeInValue_019c9f94-8505-717f-9f5c-ac16e24a2fee" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LifeInsuranceCorporateOrBankOwnedChangeInValue"/>
    <link:calculationArc order="18" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_us-gaap_LifeInsuranceCorporateOrBankOwnedChangeInValue_019c9f94-8505-717f-9f5c-ac16e24a2fee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_019c9f94-8505-78f5-9e11-c69e1555497f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes"/>
    <link:calculationArc order="19" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_019c9f94-8505-78f5-9e11-c69e1555497f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019c9f94-8505-7cb3-ae90-8baeae8bff7e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="20" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_us-gaap_ShareBasedCompensation_019c9f94-8505-7cb3-ae90-8baeae8bff7e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForOriginationOfMortgageLoansHeldForSale_019c9f94-8505-7809-8a47-72358426116a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsForOriginationOfMortgageLoansHeldForSale"/>
    <link:calculationArc order="21" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_us-gaap_PaymentsForOriginationOfMortgageLoansHeldForSale_019c9f94-8505-7809-8a47-72358426116a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfMortgageLoansHeldForSale_019c9f94-8505-79df-a02d-c27deac97bfb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromSaleOfMortgageLoansHeldForSale"/>
    <link:calculationArc order="22" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_us-gaap_ProceedsFromSaleOfMortgageLoansHeldForSale_019c9f94-8505-79df-a02d-c27deac97bfb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_019c9f94-8505-7400-a80f-c085578882f2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:calculationArc order="23" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_019c9f94-8505-7400-a80f-c085578882f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_019c9f94-8505-7a3e-9c6f-0fc53f8aaf24" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOtherOperatingLiabilities"/>
    <link:calculationArc order="24" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c9f94-8505-7c7c-810e-128cfc529aaf" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_019c9f94-8505-7a3e-9c6f-0fc53f8aaf24" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/BUSINESSCOMBINATIONSScheduleofEstimatedAcquisitiondateFairValuesoftheAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#BUSINESSCOMBINATIONSScheduleofEstimatedAcquisitiondateFairValuesoftheAssetsAcquiredandLiabilitiesAssumedDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/BUSINESSCOMBINATIONSScheduleofEstimatedAcquisitiondateFairValuesoftheAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019c9f94-8505-7ccc-aae8-48ea0ae439c0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019c9f94-8505-7906-a66e-3d399effad76" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019c9f94-8505-7ccc-aae8-48ea0ae439c0" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019c9f94-8505-7906-a66e-3d399effad76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019c9f94-8505-7668-ab17-ee81c297e528" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019c9f94-8505-7ccc-aae8-48ea0ae439c0" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019c9f94-8505-7668-ab17-ee81c297e528" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_019c9f94-8505-73c9-82f3-8a6a62e8ed34" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_PaymentsToAcquireBusinessGrossAndOtherConsiderationTransferred_019c9f94-8505-7673-a817-096d8f0b7e64" xlink:href="buse-20260331.xsd#buse_PaymentsToAcquireBusinessGrossAndOtherConsiderationTransferred"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_019c9f94-8505-73c9-82f3-8a6a62e8ed34" xlink:to="loc_buse_PaymentsToAcquireBusinessGrossAndOtherConsiderationTransferred_019c9f94-8505-7673-a817-096d8f0b7e64" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_019c9f94-8505-7d8c-a19f-3ea28acb384b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_019c9f94-8505-73c9-82f3-8a6a62e8ed34" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_019c9f94-8505-7d8c-a19f-3ea28acb384b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019c9f94-8505-7ddd-a6ea-61cda2cb8025" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesJuniorSubordinatedNotes_019c9f94-8505-79ec-9098-e20a6d0c81e7" xlink:href="buse-20260331.xsd#buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesJuniorSubordinatedNotes"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019c9f94-8505-7ddd-a6ea-61cda2cb8025" xlink:to="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesJuniorSubordinatedNotes_019c9f94-8505-79ec-9098-e20a6d0c81e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedShortTermDebt_019c9f94-8505-737e-84cd-f23f2d6d248f" xlink:href="buse-20260331.xsd#buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedShortTermDebt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019c9f94-8505-7ddd-a6ea-61cda2cb8025" xlink:to="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedShortTermDebt_019c9f94-8505-737e-84cd-f23f2d6d248f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeposits_019c9f94-8505-7ec7-b228-ff9c21649980" xlink:href="buse-20260331.xsd#buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeposits"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019c9f94-8505-7ddd-a6ea-61cda2cb8025" xlink:to="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeposits_019c9f94-8505-7ec7-b228-ff9c21649980" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherLiabilities_019c9f94-8505-757c-9b42-50921755a650" xlink:href="buse-20260331.xsd#buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019c9f94-8505-7ddd-a6ea-61cda2cb8025" xlink:to="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherLiabilities_019c9f94-8505-757c-9b42-50921755a650" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebtExcludingSubordinatedNotes_019c9f94-8505-7eb8-919d-a2290fa0f615" xlink:href="buse-20260331.xsd#buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebtExcludingSubordinatedNotes"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019c9f94-8505-7ddd-a6ea-61cda2cb8025" xlink:to="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebtExcludingSubordinatedNotes_019c9f94-8505-7eb8-919d-a2290fa0f615" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019c9f94-8505-79d5-b581-d0f09a911670" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_019c9f94-8505-764c-b03d-288df5e24f6c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019c9f94-8505-79d5-b581-d0f09a911670" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_019c9f94-8505-764c-b03d-288df5e24f6c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesFinancingReceivables_019c9f94-8505-7176-b276-00df1331408d" xlink:href="buse-20260331.xsd#buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesFinancingReceivables"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019c9f94-8505-79d5-b581-d0f09a911670" xlink:to="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesFinancingReceivables_019c9f94-8505-7176-b276-00df1331408d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_019c9f94-8505-785f-9fdc-09387563e5c2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019c9f94-8505-79d5-b581-d0f09a911670" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_019c9f94-8505-785f-9fdc-09387563e5c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_019c9f94-8505-7cf3-97f3-72b36ab20b7a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019c9f94-8505-79d5-b581-d0f09a911670" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_019c9f94-8505-7cf3-97f3-72b36ab20b7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssets_019c9f94-8505-7c06-84e8-764101326d2d" xlink:href="buse-20260331.xsd#buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019c9f94-8505-79d5-b581-d0f09a911670" xlink:to="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssets_019c9f94-8505-7c06-84e8-764101326d2d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedSecuritiesAvailableForSale_019c9f94-8505-7812-ad2c-3f833ee391a7" xlink:href="buse-20260331.xsd#buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedSecuritiesAvailableForSale"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019c9f94-8505-79d5-b581-d0f09a911670" xlink:to="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedSecuritiesAvailableForSale_019c9f94-8505-7812-ad2c-3f833ee391a7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/BUSINESSCOMBINATIONSScheduleofReconciliationBetweenthePurchasePriceandtheFairValueDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#BUSINESSCOMBINATIONSScheduleofReconciliationBetweenthePurchasePriceandtheFairValueDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/BUSINESSCOMBINATIONSScheduleofReconciliationBetweenthePurchasePriceandtheFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinancialAssets_019c9f94-8505-7479-b563-b226f56d19c9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinancialAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAcquiredReceivablesGrossContractualAmount_019c9f94-8505-7d6e-95e1-6e60ed92d0b5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationAcquiredReceivablesGrossContractualAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinancialAssets_019c9f94-8505-7479-b563-b226f56d19c9" xlink:to="loc_us-gaap_BusinessCombinationAcquiredReceivablesGrossContractualAmount_019c9f94-8505-7d6e-95e1-6e60ed92d0b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAcquiredReceivablesEstimatedUncollectible_019c9f94-8505-7f77-9e8c-b50ffbaaa8ff" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationAcquiredReceivablesEstimatedUncollectible"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinancialAssets_019c9f94-8505-7479-b563-b226f56d19c9" xlink:to="loc_us-gaap_BusinessCombinationAcquiredReceivablesEstimatedUncollectible_019c9f94-8505-7f77-9e8c-b50ffbaaa8ff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationInterestPremiumDiscountSpecificToPCDFinancialAssets_019c9f94-8505-7206-8713-3faafce64d54" xlink:href="buse-20260331.xsd#buse_BusinessCombinationInterestPremiumDiscountSpecificToPCDFinancialAssets"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinancialAssets_019c9f94-8505-7479-b563-b226f56d19c9" xlink:to="loc_buse_BusinessCombinationInterestPremiumDiscountSpecificToPCDFinancialAssets_019c9f94-8505-7206-8713-3faafce64d54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationLoansPreviouslyChargedOff_019c9f94-8505-7254-b8e6-0d21b63c3321" xlink:href="buse-20260331.xsd#buse_BusinessCombinationLoansPreviouslyChargedOff"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinancialAssets_019c9f94-8505-7479-b563-b226f56d19c9" xlink:to="loc_buse_BusinessCombinationLoansPreviouslyChargedOff_019c9f94-8505-7254-b8e6-0d21b63c3321" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/DEBTSECURITIESScheduleofAmortizedCostUnrealizedorUnrecognizedGainsandLossesandFairValuesofSecuritiesClassifiedasAFSandHTMDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#DEBTSECURITIESScheduleofAmortizedCostUnrealizedorUnrecognizedGainsandLossesandFairValuesofSecuritiesClassifiedasAFSandHTMDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/DEBTSECURITIESScheduleofAmortizedCostUnrealizedorUnrecognizedGainsandLossesandFairValuesofSecuritiesClassifiedasAFSandHTMDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8505-7c79-b3ad-c288d2524311" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019c9f94-8505-7ba9-95b2-11d88dee2f50" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8505-7c79-b3ad-c288d2524311" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019c9f94-8505-7ba9-95b2-11d88dee2f50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019c9f94-8505-785a-af47-3d65e65e8fbb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8505-7c79-b3ad-c288d2524311" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019c9f94-8505-785a-af47-3d65e65e8fbb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019c9f94-8505-797d-9dce-769b298ec591" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8505-7c79-b3ad-c288d2524311" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019c9f94-8505-797d-9dce-769b298ec591" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8505-7a9f-ace7-4cd3e07cb8f1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss_019c9f94-8505-761c-9bf5-0c4323aab979" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8505-7a9f-ace7-4cd3e07cb8f1" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss_019c9f94-8505-761c-9bf5-0c4323aab979" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesFairValue_019c9f94-8505-76cf-9df7-d7d82df7809a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8505-7a9f-ace7-4cd3e07cb8f1" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesFairValue_019c9f94-8505-76cf-9df7-d7d82df7809a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain_019c9f94-8505-7520-8cdb-1f4079c9c78a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8505-7a9f-ace7-4cd3e07cb8f1" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain_019c9f94-8505-7520-8cdb-1f4079c9c78a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/DEBTSECURITIESScheduleofMaturityofDebtSecuritiesDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#DEBTSECURITIESScheduleofMaturityofDebtSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/DEBTSECURITIESScheduleofMaturityofDebtSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019c9f94-8505-7291-8c38-3b7929473b24" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue_019c9f94-8505-740b-a3ff-a2d94ae6009f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019c9f94-8505-7291-8c38-3b7929473b24" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue_019c9f94-8505-740b-a3ff-a2d94ae6009f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue_019c9f94-8505-7d8e-bd03-89357bbc6961" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019c9f94-8505-7291-8c38-3b7929473b24" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue_019c9f94-8505-7d8e-bd03-89357bbc6961" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue_019c9f94-8505-7634-ba25-a700454b3426" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019c9f94-8505-7291-8c38-3b7929473b24" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue_019c9f94-8505-7634-ba25-a700454b3426" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenFairValue_019c9f94-8505-7980-8686-53388d47e59b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenFairValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019c9f94-8505-7291-8c38-3b7929473b24" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenFairValue_019c9f94-8505-7980-8686-53388d47e59b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8505-74c7-90b4-90a6a37d8a1e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughFive_019c9f94-8505-7749-889b-7b3c194f0275" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughFive"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8505-74c7-90b4-90a6a37d8a1e" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughFive_019c9f94-8505-7749-889b-7b3c194f0275" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateYearOne_019c9f94-8505-7450-a764-faa28027972a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateYearOne"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8505-74c7-90b4-90a6a37d8a1e" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateYearOne_019c9f94-8505-7450-a764-faa28027972a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateAfterYear10_019c9f94-8505-776c-8900-9e8980d47550" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateAfterYear10"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8505-74c7-90b4-90a6a37d8a1e" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateAfterYear10_019c9f94-8505-776c-8900-9e8980d47550" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8505-7bfe-9086-b4dbb08b7592" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsAmortizedCostBasis_019c9f94-8505-7b1f-975e-825348d56420" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsAmortizedCostBasis"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8505-7bfe-9086-b4dbb08b7592" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsAmortizedCostBasis_019c9f94-8505-7b1f-975e-825348d56420" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenAmortizedCostBasis_019c9f94-8505-74e4-9ce6-107aadf95b62" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenAmortizedCostBasis"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8505-7bfe-9086-b4dbb08b7592" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenAmortizedCostBasis_019c9f94-8505-74e4-9ce6-107aadf95b62" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenAmortizedCostBasis_019c9f94-8505-7083-b1d3-7595cfdfdbef" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenAmortizedCostBasis"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8505-7bfe-9086-b4dbb08b7592" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenAmortizedCostBasis_019c9f94-8505-7083-b1d3-7595cfdfdbef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveAmortizedCostBasis_019c9f94-8505-7323-8c32-46d956235995" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveAmortizedCostBasis"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8505-7bfe-9086-b4dbb08b7592" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveAmortizedCostBasis_019c9f94-8505-7323-8c32-46d956235995" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesFairValue_019c9f94-8505-7e13-896c-e12c7bbfd2fe" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_019c9f94-8505-77db-9157-85edb8d88cad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesFairValue_019c9f94-8505-7e13-896c-e12c7bbfd2fe" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_019c9f94-8505-77db-9157-85edb8d88cad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue_019c9f94-8505-780b-9e27-a286112c50f1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesFairValue_019c9f94-8505-7e13-896c-e12c7bbfd2fe" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue_019c9f94-8505-780b-9e27-a286112c50f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsFairValue_019c9f94-8505-7804-b31d-aab615a16968" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesFairValue_019c9f94-8505-7e13-896c-e12c7bbfd2fe" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsFairValue_019c9f94-8505-7804-b31d-aab615a16968" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/DEBTSECURITIESScheduleofRealizedGainsandLossesonDebtSecuritiesDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#DEBTSECURITIESScheduleofRealizedGainsandLossesonDebtSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/DEBTSECURITIESScheduleofRealizedGainsandLossesonDebtSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss_019c9f94-8505-784b-999d-75aabd58c1b0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss_019c9f94-8505-772a-ac9c-05d716be888c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss_019c9f94-8505-784b-999d-75aabd58c1b0" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss_019c9f94-8505-772a-ac9c-05d716be888c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGain_019c9f94-8505-7ba6-b795-0a2ee53dba34" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedGain"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss_019c9f94-8505-784b-999d-75aabd58c1b0" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGain_019c9f94-8505-7ba6-b795-0a2ee53dba34" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/DEBTSECURITIESScheduleofDebtSecuritiesinanUnrealizedorUnrecognizedLossPositionDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#DEBTSECURITIESScheduleofDebtSecuritiesinanUnrealizedorUnrecognizedLossPositionDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/DEBTSECURITIESScheduleofDebtSecuritiesinanUnrealizedorUnrecognizedLossPositionDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionAccumulatedLoss_019c9f94-8505-7b02-8562-2c3c092271e8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionAccumulatedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_019c9f94-8505-756c-898f-bb3a9af85ca1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionAccumulatedLoss_019c9f94-8505-7b02-8562-2c3c092271e8" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_019c9f94-8505-756c-898f-bb3a9af85ca1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_019c9f94-8505-77dc-b354-ebe779ad83e9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_019c9f94-8505-7717-80eb-224bef664565" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_019c9f94-8505-77dc-b354-ebe779ad83e9" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_019c9f94-8505-7717-80eb-224bef664565" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_019c9f94-8505-79ec-b9f7-3d34d77c03c2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_019c9f94-8505-77dc-b354-ebe779ad83e9" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_019c9f94-8505-79ec-b9f7-3d34d77c03c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_019c9f94-8505-7297-a85f-918e3bc3bd65" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_019c9f94-8505-7c10-81be-9d5a9af34715" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_019c9f94-8505-7297-a85f-918e3bc3bd65" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_019c9f94-8505-7c10-81be-9d5a9af34715" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_019c9f94-8505-7c77-b18a-4f6e5c1ce15d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_019c9f94-8505-7297-a85f-918e3bc3bd65" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_019c9f94-8505-7c77-b18a-4f6e5c1ce15d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionFairValue_019c9f94-8505-7437-b9b4-2a1e68182504" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_019c9f94-8505-7abc-8b26-ef76969d9cf1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionFairValue_019c9f94-8505-7437-b9b4-2a1e68182504" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_019c9f94-8505-7abc-8b26-ef76969d9cf1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/DEBTSECURITIESScheduleofAdditionalInformationonDebtSecuritiesInUnrealizedorUnrecognizedLossPositionDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#DEBTSECURITIESScheduleofAdditionalInformationonDebtSecuritiesInUnrealizedorUnrecognizedLossPositionDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/DEBTSECURITIESScheduleofAdditionalInformationonDebtSecuritiesInUnrealizedorUnrecognizedLossPositionDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_buse_TotalCountOfDebtSecurities_019c9f94-8505-7908-be90-9456ea6365b7" xlink:href="buse-20260331.xsd#buse_TotalCountOfDebtSecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_TotalCountOfDebtSecuritiesAvailableForSaleSecurities_019c9f94-8505-7707-9204-ee7aaa94c89a" xlink:href="buse-20260331.xsd#buse_TotalCountOfDebtSecuritiesAvailableForSaleSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_buse_TotalCountOfDebtSecurities_019c9f94-8505-7908-be90-9456ea6365b7" xlink:to="loc_buse_TotalCountOfDebtSecuritiesAvailableForSaleSecurities_019c9f94-8505-7707-9204-ee7aaa94c89a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_TotalCountOfDebtSecuritiesHeldToMaturity_019c9f94-8505-7969-bf47-1e3919588ca2" xlink:href="buse-20260331.xsd#buse_TotalCountOfDebtSecuritiesHeldToMaturity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_buse_TotalCountOfDebtSecurities_019c9f94-8505-7908-be90-9456ea6365b7" xlink:to="loc_buse_TotalCountOfDebtSecuritiesHeldToMaturity_019c9f94-8505-7969-bf47-1e3919588ca2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_DebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019c9f94-8505-7e78-a57f-93d27d8da47a" xlink:href="buse-20260331.xsd#buse_DebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_019c9f94-8505-7ecc-89de-2af1b37bfca1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_buse_DebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019c9f94-8505-7e78-a57f-93d27d8da47a" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_019c9f94-8505-7ecc-89de-2af1b37bfca1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionAccumulatedLoss_019c9f94-8505-7013-8df2-aa9b0a87dd61" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionAccumulatedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_buse_DebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019c9f94-8505-7e78-a57f-93d27d8da47a" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionAccumulatedLoss_019c9f94-8505-7013-8df2-aa9b0a87dd61" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_DebtSecuritiesFairValue_019c9f94-8505-727d-8db3-b1a562579280" xlink:href="buse-20260331.xsd#buse_DebtSecuritiesFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionFairValue_019c9f94-8505-7515-a51f-bd7914eb4d9f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_buse_DebtSecuritiesFairValue_019c9f94-8505-727d-8db3-b1a562579280" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionFairValue_019c9f94-8505-7515-a51f-bd7914eb4d9f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_019c9f94-8505-7fcd-b0d7-6571fed0c994" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_buse_DebtSecuritiesFairValue_019c9f94-8505-727d-8db3-b1a562579280" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_019c9f94-8505-7fcd-b0d7-6571fed0c994" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_DebtSecuritiesUnrealizedLossPositionNumberOfPositions_019c9f94-8505-7d3c-beb4-c89954a0caab" xlink:href="buse-20260331.xsd#buse_DebtSecuritiesUnrealizedLossPositionNumberOfPositions"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionNumberOfPositions_019c9f94-8505-7eeb-9854-2a6c8ec4f967" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionNumberOfPositions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_buse_DebtSecuritiesUnrealizedLossPositionNumberOfPositions_019c9f94-8505-7d3c-beb4-c89954a0caab" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionNumberOfPositions_019c9f94-8505-7eeb-9854-2a6c8ec4f967" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_DebtSecuritiesHeldToMaturityUnrealizedLossPositionNumberOfPositions_019c9f94-8505-7792-8f69-742f3912a4f5" xlink:href="buse-20260331.xsd#buse_DebtSecuritiesHeldToMaturityUnrealizedLossPositionNumberOfPositions"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_buse_DebtSecuritiesUnrealizedLossPositionNumberOfPositions_019c9f94-8505-7d3c-beb4-c89954a0caab" xlink:to="loc_buse_DebtSecuritiesHeldToMaturityUnrealizedLossPositionNumberOfPositions_019c9f94-8505-7792-8f69-742f3912a4f5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/PORTFOLIOLOANSScheduleofDistributionofPortfolioLoansDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#PORTFOLIOLOANSScheduleofDistributionofPortfolioLoansDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/PORTFOLIOLOANSScheduleofDistributionofPortfolioLoansDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_019c9f94-8505-7880-9d35-86b60559d839" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest_019c9f94-8505-768f-838c-3d4afab8fe50" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_019c9f94-8505-7880-9d35-86b60559d839" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest_019c9f94-8505-768f-838c-3d4afab8fe50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8505-77f8-9ee3-42783894650b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_019c9f94-8505-7880-9d35-86b60559d839" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8505-77f8-9ee3-42783894650b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/PORTFOLIOLOANSScheduleofCurrentYearRiskGradesofPortfolioLoansFurtherSortedbyOriginationDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#PORTFOLIOLOANSScheduleofCurrentYearRiskGradesofPortfolioLoansFurtherSortedbyOriginationDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/PORTFOLIOLOANSScheduleofCurrentYearRiskGradesofPortfolioLoansFurtherSortedbyOriginationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_buse_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLossWriteoff_019c9f94-8506-7700-abae-2e9c1d4c6a60" xlink:href="buse-20260331.xsd#buse_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLossWriteoff"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestRevolvingWriteoff_019c9f94-8506-7deb-9d8a-f027b7b827b5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestRevolvingWriteoff"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_buse_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLossWriteoff_019c9f94-8506-7700-abae-2e9c1d4c6a60" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestRevolvingWriteoff_019c9f94-8506-7deb-9d8a-f027b7b827b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearThreeOriginatedTwoYearsBeforeCurrentFiscalYearWriteoff_019c9f94-8506-7cd0-92e1-56acc05f6cbd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearThreeOriginatedTwoYearsBeforeCurrentFiscalYearWriteoff"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_buse_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLossWriteoff_019c9f94-8506-7700-abae-2e9c1d4c6a60" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearThreeOriginatedTwoYearsBeforeCurrentFiscalYearWriteoff_019c9f94-8506-7cd0-92e1-56acc05f6cbd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFourOriginatedThreeYearsBeforeCurrentFiscalYearWriteoff_019c9f94-8506-73cb-9a2a-ce5710ac491e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearFourOriginatedThreeYearsBeforeCurrentFiscalYearWriteoff"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_buse_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLossWriteoff_019c9f94-8506-7700-abae-2e9c1d4c6a60" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFourOriginatedThreeYearsBeforeCurrentFiscalYearWriteoff_019c9f94-8506-73cb-9a2a-ce5710ac491e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestOriginatedMoreThanFiveYearsBeforeCurrentFiscalYearWriteoff_019c9f94-8506-7b4f-82ed-258725f0abd2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestOriginatedMoreThanFiveYearsBeforeCurrentFiscalYearWriteoff"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_buse_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLossWriteoff_019c9f94-8506-7700-abae-2e9c1d4c6a60" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestOriginatedMoreThanFiveYearsBeforeCurrentFiscalYearWriteoff_019c9f94-8506-7b4f-82ed-258725f0abd2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFiveOriginatedFourYearsBeforeCurrentFiscalYearWriteoff_019c9f94-8506-730a-b879-48951c8c6881" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearFiveOriginatedFourYearsBeforeCurrentFiscalYearWriteoff"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_buse_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLossWriteoff_019c9f94-8506-7700-abae-2e9c1d4c6a60" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFiveOriginatedFourYearsBeforeCurrentFiscalYearWriteoff_019c9f94-8506-730a-b879-48951c8c6881" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearOneOriginatedCurrentFiscalYearWriteoff_019c9f94-8506-723b-af24-9d1e6043aefa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearOneOriginatedCurrentFiscalYearWriteoff"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_buse_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLossWriteoff_019c9f94-8506-7700-abae-2e9c1d4c6a60" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearOneOriginatedCurrentFiscalYearWriteoff_019c9f94-8506-723b-af24-9d1e6043aefa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearTwoOriginatedFiscalYearBeforeCurrentFiscalYearWriteoff_019c9f94-8506-7177-a10f-b4a7457bd4c7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearTwoOriginatedFiscalYearBeforeCurrentFiscalYearWriteoff"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_buse_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLossWriteoff_019c9f94-8506-7700-abae-2e9c1d4c6a60" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearTwoOriginatedFiscalYearBeforeCurrentFiscalYearWriteoff_019c9f94-8506-7177-a10f-b4a7457bd4c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8506-7a3b-8d36-ac6a486be95a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearOneOriginatedCurrentFiscalYear_019c9f94-8506-7f3b-b762-02a135b990f7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearOneOriginatedCurrentFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8506-7a3b-8d36-ac6a486be95a" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearOneOriginatedCurrentFiscalYear_019c9f94-8506-7f3b-b762-02a135b990f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearTwoOriginatedFiscalYearBeforeCurrentFiscalYear_019c9f94-8506-7e44-b4c4-0056d8a32b9f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearTwoOriginatedFiscalYearBeforeCurrentFiscalYear"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8506-7a3b-8d36-ac6a486be95a" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearTwoOriginatedFiscalYearBeforeCurrentFiscalYear_019c9f94-8506-7e44-b4c4-0056d8a32b9f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearThreeOriginatedTwoYearsBeforeCurrentFiscalYear_019c9f94-8506-7df5-b13a-776a0a7e3e68" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearThreeOriginatedTwoYearsBeforeCurrentFiscalYear"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8506-7a3b-8d36-ac6a486be95a" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearThreeOriginatedTwoYearsBeforeCurrentFiscalYear_019c9f94-8506-7df5-b13a-776a0a7e3e68" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFourOriginatedThreeYearsBeforeCurrentFiscalYear_019c9f94-8506-7da4-bbb2-c84a3c3ecfa2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearFourOriginatedThreeYearsBeforeCurrentFiscalYear"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8506-7a3b-8d36-ac6a486be95a" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFourOriginatedThreeYearsBeforeCurrentFiscalYear_019c9f94-8506-7da4-bbb2-c84a3c3ecfa2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFiveOriginatedFourYearsBeforeCurrentFiscalYear_019c9f94-8506-7683-88a3-8898779ee71a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearFiveOriginatedFourYearsBeforeCurrentFiscalYear"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8506-7a3b-8d36-ac6a486be95a" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFiveOriginatedFourYearsBeforeCurrentFiscalYear_019c9f94-8506-7683-88a3-8898779ee71a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestOriginatedMoreThanFiveYearsBeforeCurrentFiscalYear_019c9f94-8506-7198-a3ac-ebab39869f59" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestOriginatedMoreThanFiveYearsBeforeCurrentFiscalYear"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8506-7a3b-8d36-ac6a486be95a" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestOriginatedMoreThanFiveYearsBeforeCurrentFiscalYear_019c9f94-8506-7198-a3ac-ebab39869f59" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestRevolving_019c9f94-8506-7843-b3c5-8ce8900cb10f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestRevolving"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_019c9f94-8506-7a3b-8d36-ac6a486be95a" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestRevolving_019c9f94-8506-7843-b3c5-8ce8900cb10f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/LEASESScheduleofLeaseRelatedBalancesDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#LEASESScheduleofLeaseRelatedBalancesDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/LEASESScheduleofLeaseRelatedBalancesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_buse_LeasesRightOfUseAsset_019c9f94-8506-7de9-944b-78d36aa9ea1b" xlink:href="buse-20260331.xsd#buse_LeasesRightOfUseAsset"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019c9f94-8506-7eb9-a1f2-836782b891c2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_buse_LeasesRightOfUseAsset_019c9f94-8506-7de9-944b-78d36aa9ea1b" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019c9f94-8506-7eb9-a1f2-836782b891c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_019c9f94-8506-7cb7-aa2f-bd0ce7a10be1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseRightOfUseAsset"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_buse_LeasesRightOfUseAsset_019c9f94-8506-7de9-944b-78d36aa9ea1b" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAsset_019c9f94-8506-7cb7-aa2f-bd0ce7a10be1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_LeasesLiability_019c9f94-8506-7e07-b2b8-eae7257f2326" xlink:href="buse-20260331.xsd#buse_LeasesLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019c9f94-8506-7a87-9cc6-efe59a3d455b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_buse_LeasesLiability_019c9f94-8506-7e07-b2b8-eae7257f2326" xlink:to="loc_us-gaap_OperatingLeaseLiability_019c9f94-8506-7a87-9cc6-efe59a3d455b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_019c9f94-8506-7732-9c47-67e81d6586f3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_buse_LeasesLiability_019c9f94-8506-7e07-b2b8-eae7257f2326" xlink:to="loc_us-gaap_FinanceLeaseLiability_019c9f94-8506-7732-9c47-67e81d6586f3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/LEASESScheduleofLeaseCostsandOtherLeaseInformationDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#LEASESScheduleofLeaseCostsandOtherLeaseInformationDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/LEASESScheduleofLeaseCostsandOtherLeaseInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_019c9f94-8506-7c7f-816a-bcaafb308507" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermLeaseCost_019c9f94-8506-73f1-9214-ac977dff27dc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermLeaseCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019c9f94-8506-7c7f-816a-bcaafb308507" xlink:to="loc_us-gaap_ShortTermLeaseCost_019c9f94-8506-73f1-9214-ac977dff27dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableLeaseCost_019c9f94-8506-7cdf-a8de-6c244911b37a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_VariableLeaseCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019c9f94-8506-7c7f-816a-bcaafb308507" xlink:to="loc_us-gaap_VariableLeaseCost_019c9f94-8506-7cdf-a8de-6c244911b37a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_019c9f94-8506-7370-bcb1-1c3473e4df9e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019c9f94-8506-7c7f-816a-bcaafb308507" xlink:to="loc_us-gaap_OperatingLeaseCost_019c9f94-8506-7370-bcb1-1c3473e4df9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseInterestExpense_019c9f94-8506-7992-b95e-db2fce91e64e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseInterestExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019c9f94-8506-7c7f-816a-bcaafb308507" xlink:to="loc_us-gaap_FinanceLeaseInterestExpense_019c9f94-8506-7992-b95e-db2fce91e64e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_019c9f94-8506-72de-b9bf-a6fb200662f5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseRightOfUseAssetAmortization"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019c9f94-8506-7c7f-816a-bcaafb308507" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_019c9f94-8506-72de-b9bf-a6fb200662f5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/LEASESScheduleofFutureUndiscountedLeasePaymentsDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#LEASESScheduleofFutureUndiscountedLeasePaymentsDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/LEASESScheduleofFutureUndiscountedLeasePaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019c9f94-85b8-7fc8-ae0f-17cabe53938a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsRemainderOfFiscalYear_019c9f94-85b8-7245-baf2-16e363b88ac5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019c9f94-85b8-7fc8-ae0f-17cabe53938a" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsRemainderOfFiscalYear_019c9f94-85b8-7245-baf2-16e363b88ac5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_019c9f94-85b8-75fd-b778-01d6643bdada" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019c9f94-85b8-7fc8-ae0f-17cabe53938a" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_019c9f94-85b8-75fd-b778-01d6643bdada" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_019c9f94-85b8-796a-b084-b82af52da23a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019c9f94-85b8-7fc8-ae0f-17cabe53938a" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_019c9f94-85b8-796a-b084-b82af52da23a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_019c9f94-85b8-7eea-8a4a-d3d7dad42b22" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019c9f94-85b8-7fc8-ae0f-17cabe53938a" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_019c9f94-85b8-7eea-8a4a-d3d7dad42b22" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_019c9f94-85b8-700c-9631-b6fdc7d50ede" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019c9f94-85b8-7fc8-ae0f-17cabe53938a" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_019c9f94-85b8-700c-9631-b6fdc7d50ede" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive_019c9f94-85b8-7f04-8540-a14857947230" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019c9f94-85b8-7fc8-ae0f-17cabe53938a" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive_019c9f94-85b8-7f04-8540-a14857947230" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive_019c9f94-85b8-7d0b-9d7d-7d2d2c5848c8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019c9f94-85b8-7fc8-ae0f-17cabe53938a" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive_019c9f94-85b8-7d0b-9d7d-7d2d2c5848c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c9f94-85b8-7d3f-8048-c77099a5ca01" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019c9f94-85b8-7c19-8f3f-ddd2804dbc9d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c9f94-85b8-7d3f-8048-c77099a5ca01" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019c9f94-85b8-7c19-8f3f-ddd2804dbc9d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019c9f94-85b8-7d94-9269-e874bd86897a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c9f94-85b8-7d3f-8048-c77099a5ca01" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019c9f94-85b8-7d94-9269-e874bd86897a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019c9f94-85b8-7479-8d9a-aa494b0cf788" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c9f94-85b8-7d3f-8048-c77099a5ca01" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019c9f94-85b8-7479-8d9a-aa494b0cf788" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019c9f94-85b8-781a-998c-5f9e62b47c76" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c9f94-85b8-7d3f-8048-c77099a5ca01" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019c9f94-85b8-781a-998c-5f9e62b47c76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019c9f94-85b8-74f1-bd2a-fa51dfe85f37" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c9f94-85b8-7d3f-8048-c77099a5ca01" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019c9f94-85b8-74f1-bd2a-fa51dfe85f37" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_019c9f94-85b8-76e5-aa3a-5ee45e31cb6b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c9f94-85b8-7d3f-8048-c77099a5ca01" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_019c9f94-85b8-76e5-aa3a-5ee45e31cb6b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_019c9f94-85b8-7f23-9536-bac362e3ab52" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c9f94-85b8-7d3f-8048-c77099a5ca01" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_019c9f94-85b8-7f23-9536-bac362e3ab52" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/LEASESScheduleofFutureUndiscountedLeasePaymentsDetails_1" xlink:type="simple" xlink:href="buse-20260331.xsd#LEASESScheduleofFutureUndiscountedLeasePaymentsDetails_1"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/LEASESScheduleofFutureUndiscountedLeasePaymentsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019c9f94-85b8-7088-817f-9f8c21cf11b1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_019c9f94-85b8-7641-baef-cca0339e0d69" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019c9f94-85b8-7088-817f-9f8c21cf11b1" xlink:to="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_019c9f94-85b8-7641-baef-cca0339e0d69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_019c9f94-85b8-7fad-88ee-3e879bad3ca9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019c9f94-85b8-7088-817f-9f8c21cf11b1" xlink:to="loc_us-gaap_FinanceLeaseLiability_019c9f94-85b8-7fad-88ee-3e879bad3ca9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c9f94-85b8-777f-93ff-502d27d9e4f0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019c9f94-85b8-709e-acca-f6d85f0e51fc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c9f94-85b8-777f-93ff-502d27d9e4f0" xlink:to="loc_us-gaap_OperatingLeaseLiability_019c9f94-85b8-709e-acca-f6d85f0e51fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019c9f94-85b8-7adc-8fd2-c36f76fcfaec" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019c9f94-85b8-777f-93ff-502d27d9e4f0" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019c9f94-85b8-7adc-8fd2-c36f76fcfaec" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/LEASESScheduleofFutureMinimumLeasePaymentsDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#LEASESScheduleofFutureMinimumLeasePaymentsDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/LEASESScheduleofFutureMinimumLeasePaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_019c9f94-85b8-7e40-a698-f05ea23036b2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceived"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedRemainderOfFiscalYear_019c9f94-85b8-79b7-bd0f-6a737b5a6949" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_019c9f94-85b8-7e40-a698-f05ea23036b2" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedRemainderOfFiscalYear_019c9f94-85b8-79b7-bd0f-6a737b5a6949" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedNextTwelveMonths_019c9f94-85b8-7dce-9da5-b30ecb723982" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_019c9f94-85b8-7e40-a698-f05ea23036b2" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedNextTwelveMonths_019c9f94-85b8-7dce-9da5-b30ecb723982" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedTwoYears_019c9f94-85b8-720c-9bf4-a9d6787b1da4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedTwoYears"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_019c9f94-85b8-7e40-a698-f05ea23036b2" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedTwoYears_019c9f94-85b8-720c-9bf4-a9d6787b1da4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedThreeYears_019c9f94-85b8-7ea9-a7e6-10bbb4844ad7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedThreeYears"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_019c9f94-85b8-7e40-a698-f05ea23036b2" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedThreeYears_019c9f94-85b8-7ea9-a7e6-10bbb4844ad7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedFourYears_019c9f94-85b8-782f-9c5a-bda215e52958" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedFourYears"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_019c9f94-85b8-7e40-a698-f05ea23036b2" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedFourYears_019c9f94-85b8-782f-9c5a-bda215e52958" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/DEPOSITSScheduleofCompositionofDepositsDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#DEPOSITSScheduleofCompositionofDepositsDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/DEPOSITSScheduleofCompositionofDepositsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_019c9f94-85b8-77d3-94e0-aea5115a56fe" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Deposits"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestBearingDepositLiabilities_019c9f94-85b8-7329-a4a6-876e0e0805d1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestBearingDepositLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_019c9f94-85b8-77d3-94e0-aea5115a56fe" xlink:to="loc_us-gaap_NoninterestBearingDepositLiabilities_019c9f94-85b8-7329-a4a6-876e0e0805d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_InterestBearingTransactionDeposits_019c9f94-85b8-7c7f-a9f1-d79e9489aa2a" xlink:href="buse-20260331.xsd#buse_InterestBearingTransactionDeposits"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_019c9f94-85b8-77d3-94e0-aea5115a56fe" xlink:to="loc_buse_InterestBearingTransactionDeposits_019c9f94-85b8-7c7f-a9f1-d79e9489aa2a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_DepositsInterestBearingTransactionDepositsSavingDepositsAndMoneyMarketDeposits_019c9f94-85b8-7fb8-81e8-a923c3e279df" xlink:href="buse-20260331.xsd#buse_DepositsInterestBearingTransactionDepositsSavingDepositsAndMoneyMarketDeposits"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_019c9f94-85b8-77d3-94e0-aea5115a56fe" xlink:to="loc_buse_DepositsInterestBearingTransactionDepositsSavingDepositsAndMoneyMarketDeposits_019c9f94-85b8-7fb8-81e8-a923c3e279df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDeposits_019c9f94-85b8-78d2-9552-39453dbd5005" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimeDeposits"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_019c9f94-85b8-77d3-94e0-aea5115a56fe" xlink:to="loc_us-gaap_TimeDeposits_019c9f94-85b8-78d2-9552-39453dbd5005" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/DEPOSITSScheduleofMaturitiesofTimeDepositsDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#DEPOSITSScheduleofMaturitiesofTimeDepositsDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/DEPOSITSScheduleofMaturitiesofTimeDepositsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDeposits_019c9f94-85b8-7c2c-8dda-74cfbfed7aba" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimeDeposits"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesYearFour_019c9f94-85b8-7bb6-99f3-bdb16465951d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimeDepositMaturitiesYearFour"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_019c9f94-85b8-7c2c-8dda-74cfbfed7aba" xlink:to="loc_us-gaap_TimeDepositMaturitiesYearFour_019c9f94-85b8-7bb6-99f3-bdb16465951d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesYearTwo_019c9f94-85b8-76a4-9e85-8df508bbd47d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimeDepositMaturitiesYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_019c9f94-85b8-7c2c-8dda-74cfbfed7aba" xlink:to="loc_us-gaap_TimeDepositMaturitiesYearTwo_019c9f94-85b8-76a4-9e85-8df508bbd47d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesYearFive_019c9f94-85b8-75d7-8f1d-405ccfab8fa5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimeDepositMaturitiesYearFive"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_019c9f94-85b8-7c2c-8dda-74cfbfed7aba" xlink:to="loc_us-gaap_TimeDepositMaturitiesYearFive_019c9f94-85b8-75d7-8f1d-405ccfab8fa5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesAfterYearFive_019c9f94-85b8-72a9-a2c9-f52740002e7d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimeDepositMaturitiesAfterYearFive"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_019c9f94-85b8-7c2c-8dda-74cfbfed7aba" xlink:to="loc_us-gaap_TimeDepositMaturitiesAfterYearFive_019c9f94-85b8-72a9-a2c9-f52740002e7d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesYearOne_019c9f94-85b8-7e20-b588-1e65e0debfa3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimeDepositMaturitiesYearOne"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_019c9f94-85b8-7c2c-8dda-74cfbfed7aba" xlink:to="loc_us-gaap_TimeDepositMaturitiesYearOne_019c9f94-85b8-7e20-b588-1e65e0debfa3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesYearThree_019c9f94-85b8-70b4-8121-288775ff5bd5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimeDepositMaturitiesYearThree"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_019c9f94-85b8-7c2c-8dda-74cfbfed7aba" xlink:to="loc_us-gaap_TimeDepositMaturitiesYearThree_019c9f94-85b8-70b4-8121-288775ff5bd5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesRemainderOfFiscalYear_019c9f94-85b8-7f6c-be6c-dfa150dcb896" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimeDepositMaturitiesRemainderOfFiscalYear"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_019c9f94-85b8-7c2c-8dda-74cfbfed7aba" xlink:to="loc_us-gaap_TimeDepositMaturitiesRemainderOfFiscalYear_019c9f94-85b8-7f6c-be6c-dfa150dcb896" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/BORROWINGSScheduleofLongtermBorrowingsDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#BORROWINGSScheduleofLongtermBorrowingsDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/BORROWINGSScheduleofLongtermBorrowingsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_019c9f94-85b9-76cd-81ac-c78ead5846ef" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019c9f94-85b9-7359-98e0-e8b46f06e4a2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_019c9f94-85b9-76cd-81ac-c78ead5846ef" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019c9f94-85b9-7359-98e0-e8b46f06e4a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_019c9f94-85b9-73d5-baac-61856df39bea" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_019c9f94-85b9-76cd-81ac-c78ead5846ef" xlink:to="loc_us-gaap_FinanceLeaseLiability_019c9f94-85b9-73d5-baac-61856df39bea" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/DERIVATIVEFINANCIALINSTRUMENTSScheduleofNetGainsLossesRecordedinAOCIDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#DERIVATIVEFINANCIALINSTRUMENTSScheduleofNetGainsLossesRecordedinAOCIDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/DERIVATIVEFINANCIALINSTRUMENTSScheduleofNetGainsLossesRecordedinAOCIDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeExcludedComponentGainLossRecognizedInEarnings_019c9f94-85b9-7fd8-92cd-5ff2fb768e3a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DerivativeExcludedComponentGainLossRecognizedInEarnings"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019c9f94-85b9-74fe-b45d-bd9d0972ff4f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeExcludedComponentGainLossRecognizedInEarnings_019c9f94-85b9-7fd8-92cd-5ff2fb768e3a" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019c9f94-85b9-74fe-b45d-bd9d0972ff4f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationToInterestIncomeBeforeTax_019c9f94-85b9-7f33-ac05-91ab8c47bf32" xlink:href="buse-20260331.xsd#buse_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationToInterestIncomeBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeExcludedComponentGainLossRecognizedInEarnings_019c9f94-85b9-7fd8-92cd-5ff2fb768e3a" xlink:to="loc_buse_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationToInterestIncomeBeforeTax_019c9f94-85b9-7f33-ac05-91ab8c47bf32" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/DERIVATIVEFINANCIALINSTRUMENTSScheduleofInterestRateSwapsRecordedinNoninterestExpenseDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#DERIVATIVEFINANCIALINSTRUMENTSScheduleofInterestRateSwapsRecordedinNoninterestExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/DERIVATIVEFINANCIALINSTRUMENTSScheduleofInterestRateSwapsRecordedinNoninterestExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_019c9f94-85b9-74b4-bdec-793c8a5d1fad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DerivativeGainLossOnDerivativeNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_DerivativeGainLossesOnDerivativePayFixedReceiveFloating_019c9f94-85b9-7ff7-b72e-7603b047be81" xlink:href="buse-20260331.xsd#buse_DerivativeGainLossesOnDerivativePayFixedReceiveFloating"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeGainLossOnDerivativeNet_019c9f94-85b9-74b4-bdec-793c8a5d1fad" xlink:to="loc_buse_DerivativeGainLossesOnDerivativePayFixedReceiveFloating_019c9f94-85b9-7ff7-b72e-7603b047be81" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_DerivativeGainLossesOnDerivativePayFloatingReceiveFixed_019c9f94-85b9-7aac-82c4-2f96a05b18c2" xlink:href="buse-20260331.xsd#buse_DerivativeGainLossesOnDerivativePayFloatingReceiveFixed"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeGainLossOnDerivativeNet_019c9f94-85b9-74b4-bdec-793c8a5d1fad" xlink:to="loc_buse_DerivativeGainLossesOnDerivativePayFloatingReceiveFixed_019c9f94-85b9-7aac-82c4-2f96a05b18c2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/EARNINGSPERCOMMONSHAREScheduleofComputationofEarningsPerCommonShareDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#EARNINGSPERCOMMONSHAREScheduleofComputationofEarningsPerCommonShareDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/EARNINGSPERCOMMONSHAREScheduleofComputationofEarningsPerCommonShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019c9f94-85b9-7301-825a-c661673c9758" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019c9f94-85b9-737e-81b0-de3eacfdcab6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019c9f94-85b9-7301-825a-c661673c9758" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019c9f94-85b9-737e-81b0-de3eacfdcab6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_019c9f94-85b9-7dce-b532-66b031310e39" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019c9f94-85b9-7301-825a-c661673c9758" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_019c9f94-85b9-7dce-b532-66b031310e39" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/OPERATINGSEGMENTSANDRELATEDINFORMATIONScheduleofFinancialResultsbyOperatingSegmentDetails" xlink:type="simple" xlink:href="buse-20260331.xsd#OPERATINGSEGMENTSANDRELATEDINFORMATIONScheduleofFinancialResultsbyOperatingSegmentDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/OPERATINGSEGMENTSANDRELATEDINFORMATIONScheduleofFinancialResultsbyOperatingSegmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_019c9f94-85b9-735c-9621-fcb423921ad0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_IntersegmentNoninterestIncome_019c9f94-85b9-79eb-9b85-0ae682dce535" xlink:href="buse-20260331.xsd#buse_IntersegmentNoninterestIncome"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_019c9f94-85b9-735c-9621-fcb423921ad0" xlink:to="loc_buse_IntersegmentNoninterestIncome_019c9f94-85b9-79eb-9b85-0ae682dce535" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_019c9f94-85b9-71e8-9bbe-367f76759cbb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_019c9f94-85b9-735c-9621-fcb423921ad0" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_019c9f94-85b9-71e8-9bbe-367f76759cbb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncomeOther_019c9f94-85b9-7f2b-a8db-e62c22951939" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestIncomeOther"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_019c9f94-85b9-735c-9621-fcb423921ad0" xlink:to="loc_us-gaap_NoninterestIncomeOther_019c9f94-85b9-7f2b-a8db-e62c22951939" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_019c9f94-85b9-7fbe-bc3d-c05c083303b8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_019c9f94-85b9-7d17-a9b5-0c2c19b802c1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_019c9f94-85b9-7fbe-bc3d-c05c083303b8" xlink:to="loc_us-gaap_LaborAndRelatedExpense_019c9f94-85b9-7d17-a9b5-0c2c19b802c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InformationTechnologyAndDataProcessing_019c9f94-85b9-7a4d-957d-4d0c6004d034" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InformationTechnologyAndDataProcessing"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_019c9f94-85b9-7fbe-bc3d-c05c083303b8" xlink:to="loc_us-gaap_InformationTechnologyAndDataProcessing_019c9f94-85b9-7a4d-957d-4d0c6004d034" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_IntersegmentNoninterestExpense_019c9f94-85b9-78c1-ba3b-d51ede31f239" xlink:href="buse-20260331.xsd#buse_IntersegmentNoninterestExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_019c9f94-85b9-7fbe-bc3d-c05c083303b8" xlink:to="loc_buse_IntersegmentNoninterestExpense_019c9f94-85b9-78c1-ba3b-d51ede31f239" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019c9f94-85b9-72a7-b220-728b4640dbd4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_019c9f94-85b9-7fbe-bc3d-c05c083303b8" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019c9f94-85b9-72a7-b220-728b4640dbd4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_OtherNoninterestExpenseAdjusted_019c9f94-85b9-70ea-b910-4256572c98fd" xlink:href="buse-20260331.xsd#buse_OtherNoninterestExpenseAdjusted"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_019c9f94-85b9-7fbe-bc3d-c05c083303b8" xlink:to="loc_buse_OtherNoninterestExpenseAdjusted_019c9f94-85b9-70ea-b910-4256572c98fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_InterchangeExpense_019c9f94-85b9-7cff-bd57-eb2f1ee723d9" xlink:href="buse-20260331.xsd#buse_InterchangeExpense"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_019c9f94-85b9-7fbe-bc3d-c05c083303b8" xlink:to="loc_buse_InterchangeExpense_019c9f94-85b9-7cff-bd57-eb2f1ee723d9" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
