<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2025 Workiva-->
<!--r:782f51c3-703a-4eb3-a98f-e9788471aa8c,g:d664303b-b948-434e-8124-2b1e42075175-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.busey.com/role/CONSOLIDATEDBALANCESHEETSUnaudited" xlink:type="simple" xlink:href="buse-20250930.xsd#CONSOLIDATEDBALANCESHEETSUnaudited"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/CONSOLIDATEDBALANCESHEETSUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_1b0211e0-7e90-46ce-a435-024772feffd4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_7f450dfc-4acf-4b54-9f8d-2f6412ce1c56" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_1b0211e0-7e90-46ce-a435-024772feffd4" xlink:to="loc_us-gaap_Liabilities_7f450dfc-4acf-4b54-9f8d-2f6412ce1c56" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_9a1b352e-6faf-4675-bb81-c430ff3518b2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_1b0211e0-7e90-46ce-a435-024772feffd4" xlink:to="loc_us-gaap_StockholdersEquity_9a1b352e-6faf-4675-bb81-c430ff3518b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_ac30481a-9f7b-4c03-9d7b-b0543f33fc37" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_1b0211e0-7e90-46ce-a435-024772feffd4" xlink:to="loc_us-gaap_CommitmentsAndContingencies_ac30481a-9f7b-4c03-9d7b-b0543f33fc37" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_0e4d2328-ba8f-42dc-abcc-c3e4f0f7e346" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityBeforeTreasuryStock_4454bec2-0533-499e-a57d-6f2bb40f82e0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquityBeforeTreasuryStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_0e4d2328-ba8f-42dc-abcc-c3e4f0f7e346" xlink:to="loc_us-gaap_StockholdersEquityBeforeTreasuryStock_4454bec2-0533-499e-a57d-6f2bb40f82e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_ecd11871-5b66-4fbd-b0cf-189d50fc5b0b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_0e4d2328-ba8f-42dc-abcc-c3e4f0f7e346" xlink:to="loc_us-gaap_TreasuryStockValue_ecd11871-5b66-4fbd-b0cf-189d50fc5b0b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_6dda5dd6-9f6d-4c14-a4db-8286d46d127d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestBearingDepositsInBanks_e9ccaae2-a824-4a4d-bcc1-32ba235ac7d7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestBearingDepositsInBanks"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_6dda5dd6-9f6d-4c14-a4db-8286d46d127d" xlink:to="loc_us-gaap_InterestBearingDepositsInBanks_e9ccaae2-a824-4a4d-bcc1-32ba235ac7d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndDueFromBanks_862cd34a-277d-4429-9de7-b9bfdd9b333d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndDueFromBanks"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_6dda5dd6-9f6d-4c14-a4db-8286d46d127d" xlink:to="loc_us-gaap_CashAndDueFromBanks_862cd34a-277d-4429-9de7-b9bfdd9b333d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_601b5014-dde8-4777-8e62-5e7db659a880" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_2052d732-419b-456f-b24b-be6de6f25641" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_601b5014-dde8-4777-8e62-5e7db659a880" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_2052d732-419b-456f-b24b-be6de6f25641" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_849e40fd-d51b-410c-b2a5-b8ee66f574e5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_601b5014-dde8-4777-8e62-5e7db659a880" xlink:to="loc_us-gaap_Goodwill_849e40fd-d51b-410c-b2a5-b8ee66f574e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_2902ce5e-8757-49ba-84cc-c4c070de23c3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_601b5014-dde8-4777-8e62-5e7db659a880" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_2902ce5e-8757-49ba-84cc-c4c070de23c3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_8a065425-9874-44eb-aae2-fdb1e05fa72f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_601b5014-dde8-4777-8e62-5e7db659a880" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_8a065425-9874-44eb-aae2-fdb1e05fa72f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssets_46598c66-2f61-426a-b6da-c318ef5073dd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_601b5014-dde8-4777-8e62-5e7db659a880" xlink:to="loc_us-gaap_OtherAssets_46598c66-2f61-426a-b6da-c318ef5073dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_c6bea054-7d47-43e5-a2e1-c06f834aa1d5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_601b5014-dde8-4777-8e62-5e7db659a880" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_c6bea054-7d47-43e5-a2e1-c06f834aa1d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankStockAndFederalReserveBankStock_7edf52dd-0230-473d-ab99-68296380b071" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FederalHomeLoanBankStockAndFederalReserveBankStock"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_601b5014-dde8-4777-8e62-5e7db659a880" xlink:to="loc_us-gaap_FederalHomeLoanBankStockAndFederalReserveBankStock_7edf52dd-0230-473d-ab99-68296380b071" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_fad656a2-7e28-4878-87f5-475f337e9006" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_601b5014-dde8-4777-8e62-5e7db659a880" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_fad656a2-7e28-4878-87f5-475f337e9006" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_9e52b1ed-5d7d-4e43-8a95-28b7f3d08530" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_601b5014-dde8-4777-8e62-5e7db659a880" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_9e52b1ed-5d7d-4e43-8a95-28b7f3d08530" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroup_ccfe15f8-28d0-42c9-b61e-c36254808dc1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroup"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_601b5014-dde8-4777-8e62-5e7db659a880" xlink:to="loc_us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroup_ccfe15f8-28d0-42c9-b61e-c36254808dc1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashSurrenderValueOfLifeInsurance_d9a9d124-6391-4c55-84dc-8902da4cdf6c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashSurrenderValueOfLifeInsurance"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_601b5014-dde8-4777-8e62-5e7db659a880" xlink:to="loc_us-gaap_CashSurrenderValueOfLifeInsurance_d9a9d124-6391-4c55-84dc-8902da4cdf6c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_956fa2d9-0029-41ae-98eb-6bb5d776f38c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_601b5014-dde8-4777-8e62-5e7db659a880" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_956fa2d9-0029-41ae-98eb-6bb5d776f38c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_4935c1cf-1890-4360-9d28-7803942c57e9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_560c5354-bb1a-4cba-9898-ef2948e1dd91" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Deposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4935c1cf-1890-4360-9d28-7803942c57e9" xlink:to="loc_us-gaap_Deposits_560c5354-bb1a-4cba-9898-ef2948e1dd91" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_b1684955-9fb6-447c-a699-13eba379f9c2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4935c1cf-1890-4360-9d28-7803942c57e9" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_b1684955-9fb6-447c-a699-13eba379f9c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubordinatedDebt_9165cdf7-f908-403c-b7af-d8992abb10fe" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubordinatedDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4935c1cf-1890-4360-9d28-7803942c57e9" xlink:to="loc_us-gaap_SubordinatedDebt_9165cdf7-f908-403c-b7af-d8992abb10fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_LongTermDebtExcludingSeniorNotesSubordinatedNotesAndJuniorSubordinated_5917e65d-c331-4ffa-aa14-e43eac00dd85" xlink:href="buse-20250930.xsd#buse_LongTermDebtExcludingSeniorNotesSubordinatedNotesAndJuniorSubordinated"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4935c1cf-1890-4360-9d28-7803942c57e9" xlink:to="loc_buse_LongTermDebtExcludingSeniorNotesSubordinatedNotesAndJuniorSubordinated_5917e65d-c331-4ffa-aa14-e43eac00dd85" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_JuniorSubordinatedDebentureOwedToUnconsolidatedSubsidiaryTrust_6ed97a57-b2c3-4944-b45c-036fd3c2fa8a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_JuniorSubordinatedDebentureOwedToUnconsolidatedSubsidiaryTrust"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4935c1cf-1890-4360-9d28-7803942c57e9" xlink:to="loc_us-gaap_JuniorSubordinatedDebentureOwedToUnconsolidatedSubsidiaryTrust_6ed97a57-b2c3-4944-b45c-036fd3c2fa8a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilities_8e13a2c8-a8a1-4bba-bca5-ee759c03aac3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4935c1cf-1890-4360-9d28-7803942c57e9" xlink:to="loc_us-gaap_OtherLiabilities_8e13a2c8-a8a1-4bba-bca5-ee759c03aac3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityBeforeTreasuryStock_340bf292-6ccb-4bdf-b538-da5ac0ac8e11" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquityBeforeTreasuryStock"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_ed0bd3a3-4ff3-419e-bbbe-15d8af3eaeec" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityBeforeTreasuryStock_340bf292-6ccb-4bdf-b538-da5ac0ac8e11" xlink:to="loc_us-gaap_CommonStockValue_ed0bd3a3-4ff3-419e-bbbe-15d8af3eaeec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_9a370772-f191-4ca1-9283-0b2d60af96e7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityBeforeTreasuryStock_340bf292-6ccb-4bdf-b538-da5ac0ac8e11" xlink:to="loc_us-gaap_AdditionalPaidInCapital_9a370772-f191-4ca1-9283-0b2d60af96e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_d0425ea6-13fc-4338-87fe-8542200e15a5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityBeforeTreasuryStock_340bf292-6ccb-4bdf-b538-da5ac0ac8e11" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_d0425ea6-13fc-4338-87fe-8542200e15a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_6bfba8b8-5e56-467f-818c-294cc8a9a7d7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityBeforeTreasuryStock_340bf292-6ccb-4bdf-b538-da5ac0ac8e11" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_6bfba8b8-5e56-467f-818c-294cc8a9a7d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_1b50dce5-3e93-4cf4-b8cc-c0ed70613243" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityBeforeTreasuryStock_340bf292-6ccb-4bdf-b538-da5ac0ac8e11" xlink:to="loc_us-gaap_PreferredStockValue_1b50dce5-3e93-4cf4-b8cc-c0ed70613243" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_60e6ed7b-1b0b-420c-988f-6a7a6e94482b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Deposits"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestBearingDepositLiabilities_a7600090-cc8b-4a87-b63d-77a4dd859d6d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestBearingDepositLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_60e6ed7b-1b0b-420c-988f-6a7a6e94482b" xlink:to="loc_us-gaap_NoninterestBearingDepositLiabilities_a7600090-cc8b-4a87-b63d-77a4dd859d6d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestBearingDepositLiabilities_4adcbb8f-941d-4930-b27e-db8e6e63e9af" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestBearingDepositLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_60e6ed7b-1b0b-420c-988f-6a7a6e94482b" xlink:to="loc_us-gaap_InterestBearingDepositLiabilities_4adcbb8f-941d-4930-b27e-db8e6e63e9af" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/CONSOLIDATEDSTATEMENTSOFINCOMEUnaudited" xlink:type="simple" xlink:href="buse-20250930.xsd#CONSOLIDATEDSTATEMENTSOFINCOMEUnaudited"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/CONSOLIDATEDSTATEMENTSOFINCOMEUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseOperating_985b1f0a-3a83-4664-a923-db787511c972" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseOperating"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDeposits_56e53e32-4e92-4d4f-af5c-63d368e0e345" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseDeposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseOperating_985b1f0a-3a83-4664-a923-db787511c972" xlink:to="loc_us-gaap_InterestExpenseDeposits_56e53e32-4e92-4d4f-af5c-63d368e0e345" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseSecuritiesSoldUnderAgreementsToRepurchase_b077095c-4d3d-4891-9e30-a5f6233100ad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseSecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseOperating_985b1f0a-3a83-4664-a923-db787511c972" xlink:to="loc_us-gaap_InterestExpenseSecuritiesSoldUnderAgreementsToRepurchase_b077095c-4d3d-4891-9e30-a5f6233100ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseShortTermBorrowingsExcludingFederalFundsAndSecuritiesSoldUnderAgreementsToRepurchase_c30dcf1e-8d2f-4e4e-9f31-f8253ce7ddb1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseShortTermBorrowingsExcludingFederalFundsAndSecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseOperating_985b1f0a-3a83-4664-a923-db787511c972" xlink:to="loc_us-gaap_InterestExpenseShortTermBorrowingsExcludingFederalFundsAndSecuritiesSoldUnderAgreementsToRepurchase_c30dcf1e-8d2f-4e4e-9f31-f8253ce7ddb1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseOtherLongTermDebt_afba88e1-271a-4448-be18-49dcd863b11a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseOtherLongTermDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseOperating_985b1f0a-3a83-4664-a923-db787511c972" xlink:to="loc_us-gaap_InterestExpenseOtherLongTermDebt_afba88e1-271a-4448-be18-49dcd863b11a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseSubordinatedNotesAndDebentures_31ecb31d-ad3f-4fc9-9dbc-6fd3280f40bc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseSubordinatedNotesAndDebentures"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseOperating_985b1f0a-3a83-4664-a923-db787511c972" xlink:to="loc_us-gaap_InterestExpenseSubordinatedNotesAndDebentures_31ecb31d-ad3f-4fc9-9dbc-6fd3280f40bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseJuniorSubordinatedDebentures_61e4772d-81b9-4c9d-9785-848fa16b6744" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseJuniorSubordinatedDebentures"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseOperating_985b1f0a-3a83-4664-a923-db787511c972" xlink:to="loc_us-gaap_InterestExpenseJuniorSubordinatedDebentures_61e4772d-81b9-4c9d-9785-848fa16b6744" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_9b547ae4-015e-4ebe-8fde-057949b48d99" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_dc70654c-4ea4-46c6-ae7e-80cd29fb33bc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9b547ae4-015e-4ebe-8fde-057949b48d99" xlink:to="loc_us-gaap_LaborAndRelatedExpense_dc70654c-4ea4-46c6-ae7e-80cd29fb33bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OccupancyNet_a63f6f81-e44e-4a3d-a7c2-82b7a01dbe3d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OccupancyNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9b547ae4-015e-4ebe-8fde-057949b48d99" xlink:to="loc_us-gaap_OccupancyNet_a63f6f81-e44e-4a3d-a7c2-82b7a01dbe3d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquipmentExpense_bf19fcf4-defc-4ed4-bb4b-a8a45a42fa93" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquipmentExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9b547ae4-015e-4ebe-8fde-057949b48d99" xlink:to="loc_us-gaap_EquipmentExpense_bf19fcf4-defc-4ed4-bb4b-a8a45a42fa93" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InformationTechnologyAndDataProcessing_b34b7e55-c131-4ff2-ad38-b7df51a16307" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InformationTechnologyAndDataProcessing"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9b547ae4-015e-4ebe-8fde-057949b48d99" xlink:to="loc_us-gaap_InformationTechnologyAndDataProcessing_b34b7e55-c131-4ff2-ad38-b7df51a16307" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfessionalFees_7a3aa93d-d71c-49a1-9b7a-6c2d4d9e276f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProfessionalFees"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9b547ae4-015e-4ebe-8fde-057949b48d99" xlink:to="loc_us-gaap_ProfessionalFees_7a3aa93d-d71c-49a1-9b7a-6c2d4d9e276f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_d2094b3b-4eca-425b-8258-cfcfa677648e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9b547ae4-015e-4ebe-8fde-057949b48d99" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_d2094b3b-4eca-425b-8258-cfcfa677648e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_InterchangeExpense_5368b832-69dc-444a-9d50-ab746216d8d2" xlink:href="buse-20250930.xsd#buse_InterchangeExpense"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9b547ae4-015e-4ebe-8fde-057949b48d99" xlink:to="loc_buse_InterchangeExpense_5368b832-69dc-444a-9d50-ab746216d8d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoninterestExpense_c2187faf-62d9-4a9c-baf4-8acb1f221016" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNoninterestExpense"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9b547ae4-015e-4ebe-8fde-057949b48d99" xlink:to="loc_us-gaap_OtherNoninterestExpense_c2187faf-62d9-4a9c-baf4-8acb1f221016" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalDepositInsuranceCorporationPremiumExpense_e53f0c49-fad9-433c-ae5a-7892070d8805" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FederalDepositInsuranceCorporationPremiumExpense"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9b547ae4-015e-4ebe-8fde-057949b48d99" xlink:to="loc_us-gaap_FederalDepositInsuranceCorporationPremiumExpense_e53f0c49-fad9-433c-ae5a-7892070d8805" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_9b7d4c9e-9fb2-4f32-a8cb-ddfc84b5ade7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_f8c2ccf1-c188-469b-bac3-ffe9cc8eb28d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_9b7d4c9e-9fb2-4f32-a8cb-ddfc84b5ade7" xlink:to="loc_us-gaap_InterestAndDividendIncomeOperating_f8c2ccf1-c188-469b-bac3-ffe9cc8eb28d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseOperating_86cb099f-7036-4e2c-921d-425b86a667b8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseOperating"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_9b7d4c9e-9fb2-4f32-a8cb-ddfc84b5ade7" xlink:to="loc_us-gaap_InterestExpenseOperating_86cb099f-7036-4e2c-921d-425b86a667b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_4b70a87a-a92d-476d-a5d4-6e958700fa0f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_02feeff8-d414-4df9-a2f0-9a0511495bb6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_4b70a87a-a92d-476d-a5d4-6e958700fa0f" xlink:to="loc_us-gaap_NetIncomeLoss_02feeff8-d414-4df9-a2f0-9a0511495bb6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_0f5f6d64-f657-41de-a603-1f8acce027e2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockDividendsIncomeStatementImpact"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_4b70a87a-a92d-476d-a5d4-6e958700fa0f" xlink:to="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_0f5f6d64-f657-41de-a603-1f8acce027e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_cca737d8-84eb-4b74-a43e-5ac706589d10" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndFeeIncomeLoansAndLeases_07c397d1-3876-4bc4-993a-1c19e415d341" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestAndFeeIncomeLoansAndLeases"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_cca737d8-84eb-4b74-a43e-5ac706589d10" xlink:to="loc_us-gaap_InterestAndFeeIncomeLoansAndLeases_07c397d1-3876-4bc4-993a-1c19e415d341" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesTaxable_2857cd0d-c6ea-49e5-8346-265587263463" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeSecuritiesTaxable"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_cca737d8-84eb-4b74-a43e-5ac706589d10" xlink:to="loc_us-gaap_InterestIncomeSecuritiesTaxable_2857cd0d-c6ea-49e5-8346-265587263463" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeDividend_b9b894a8-7c05-4ac4-99c7-257c8214986f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InvestmentIncomeDividend"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_cca737d8-84eb-4b74-a43e-5ac706589d10" xlink:to="loc_us-gaap_InvestmentIncomeDividend_b9b894a8-7c05-4ac4-99c7-257c8214986f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesTaxExempt_5b5ca8d0-a09d-4dd6-8c39-24df93a99d19" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeSecuritiesTaxExempt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_cca737d8-84eb-4b74-a43e-5ac706589d10" xlink:to="loc_us-gaap_InterestIncomeSecuritiesTaxExempt_5b5ca8d0-a09d-4dd6-8c39-24df93a99d19" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeOther_5e4b9823-9173-414d-b105-85e6594e04b3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeOther"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_cca737d8-84eb-4b74-a43e-5ac706589d10" xlink:to="loc_us-gaap_InterestIncomeOther_5e4b9823-9173-414d-b105-85e6594e04b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_ece07538-931e-4558-8585-9d958bda2e88" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_d867a840-da67-46ae-9776-585f32f80f5a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_ece07538-931e-4558-8585-9d958bda2e88" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_d867a840-da67-46ae-9776-585f32f80f5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfMortgageLoans_165bd75b-70a8-4efe-8aad-b0a866b3f08b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GainLossOnSaleOfMortgageLoans"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_ece07538-931e-4558-8585-9d958bda2e88" xlink:to="loc_us-gaap_GainLossOnSaleOfMortgageLoans_165bd75b-70a8-4efe-8aad-b0a866b3f08b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankOwnedLifeInsuranceIncome_802fb1fa-7daf-48e6-b276-7cb6b5433bea" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BankOwnedLifeInsuranceIncome"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_ece07538-931e-4558-8585-9d958bda2e88" xlink:to="loc_us-gaap_BankOwnedLifeInsuranceIncome_802fb1fa-7daf-48e6-b276-7cb6b5433bea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtAndEquitySecuritiesRealizedGainLoss_c9982110-4e70-4ec1-b244-3203658dc77a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtAndEquitySecuritiesRealizedGainLoss"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_ece07538-931e-4558-8585-9d958bda2e88" xlink:to="loc_us-gaap_DebtAndEquitySecuritiesRealizedGainLoss_c9982110-4e70-4ec1-b244-3203658dc77a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_dd7fbce7-ecc7-4d50-a980-5e11959a80c2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_ece07538-931e-4558-8585-9d958bda2e88" xlink:to="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_dd7fbce7-ecc7-4d50-a980-5e11959a80c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncomeOtherOperatingIncome_7f3da6e4-794b-4a9c-8fcf-1b4c027f3afc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestIncomeOtherOperatingIncome"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_ece07538-931e-4558-8585-9d958bda2e88" xlink:to="loc_us-gaap_NoninterestIncomeOtherOperatingIncome_7f3da6e4-794b-4a9c-8fcf-1b4c027f3afc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_GainLossOnSalesOfMortgageServicingRightsMSR_f9b3b15b-c7cc-4588-9213-f27b7e96a925" xlink:href="buse-20250930.xsd#buse_GainLossOnSalesOfMortgageServicingRightsMSR"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_ece07538-931e-4558-8585-9d958bda2e88" xlink:to="loc_buse_GainLossOnSalesOfMortgageServicingRightsMSR_f9b3b15b-c7cc-4588-9213-f27b7e96a925" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_7b7839d4-6117-4993-94c9-cac81931ef34" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_23b02e0c-2b90-4b05-afad-dbb49c084c65" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_7b7839d4-6117-4993-94c9-cac81931ef34" xlink:to="loc_us-gaap_InterestIncomeExpenseNet_23b02e0c-2b90-4b05-afad-dbb49c084c65" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanLossesExpensed_63b9aa2f-a1a6-4a8c-a029-9ac03ad75282" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProvisionForLoanLossesExpensed"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_7b7839d4-6117-4993-94c9-cac81931ef34" xlink:to="loc_us-gaap_ProvisionForLoanLossesExpensed_63b9aa2f-a1a6-4a8c-a029-9ac03ad75282" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_5f1e84e7-0ac7-4c2a-af31-36b3b3cda76a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_c4f5457d-b9f2-4c64-872a-0cae2b395317" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_5f1e84e7-0ac7-4c2a-af31-36b3b3cda76a" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_c4f5457d-b9f2-4c64-872a-0cae2b395317" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_8d4f319c-b0c0-4873-a23c-acf582f17537" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_5f1e84e7-0ac7-4c2a-af31-36b3b3cda76a" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_8d4f319c-b0c0-4873-a23c-acf582f17537" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_4c9c1077-c867-4844-92d9-5b0f773243e6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_906cd690-1199-49ab-a7fa-445e6e2e5647" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_4c9c1077-c867-4844-92d9-5b0f773243e6" xlink:to="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_906cd690-1199-49ab-a7fa-445e6e2e5647" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_6bfc2a9a-542b-42d0-80df-bdf311e48076" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_4c9c1077-c867-4844-92d9-5b0f773243e6" xlink:to="loc_us-gaap_NoninterestIncome_6bfc2a9a-542b-42d0-80df-bdf311e48076" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_dc6f2871-6bdf-45ce-912c-64040aef2417" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_4c9c1077-c867-4844-92d9-5b0f773243e6" xlink:to="loc_us-gaap_NoninterestExpense_dc6f2871-6bdf-45ce-912c-64040aef2417" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUnaudited" xlink:type="simple" xlink:href="buse-20250930.xsd#CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUnaudited"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_e31e0f3e-8311-4059-b1ba-9cbe2531878d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_ab447ec9-3da5-4e95-a708-4018d113b429" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_e31e0f3e-8311-4059-b1ba-9cbe2531878d" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_ab447ec9-3da5-4e95-a708-4018d113b429" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationTax_02bce95c-dacd-47c1-ae96-2a7cac59dad0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_e31e0f3e-8311-4059-b1ba-9cbe2531878d" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationTax_02bce95c-dacd-47c1-ae96-2a7cac59dad0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_8dad704d-4fbc-4482-a4b3-fd055cae59e8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_e31e0f3e-8311-4059-b1ba-9cbe2531878d" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_8dad704d-4fbc-4482-a4b3-fd055cae59e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_1429f4ce-f336-497c-9b3c-deddc0b21f8e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_0bfce9aa-f7e0-448e-ac6b-d9a308aa3e28" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_1429f4ce-f336-497c-9b3c-deddc0b21f8e" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_0bfce9aa-f7e0-448e-ac6b-d9a308aa3e28" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_a5dcdb42-9998-44df-b66e-c806e24cc682" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_1429f4ce-f336-497c-9b3c-deddc0b21f8e" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_a5dcdb42-9998-44df-b66e-c806e24cc682" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_a1321270-dc65-4566-ad86-989e84545b28" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_1429f4ce-f336-497c-9b3c-deddc0b21f8e" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_a1321270-dc65-4566-ad86-989e84545b28" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OciDebtSecuritiesAvailableForSaleTransferToHeldToMaturityAdjustmentFromAociForAmortizationOfGainLossBeforeTax_a5d70866-0618-4037-8f61-22c1bf21d6ef" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OciDebtSecuritiesAvailableForSaleTransferToHeldToMaturityAdjustmentFromAociForAmortizationOfGainLossBeforeTax"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_1429f4ce-f336-497c-9b3c-deddc0b21f8e" xlink:to="loc_us-gaap_OciDebtSecuritiesAvailableForSaleTransferToHeldToMaturityAdjustmentFromAociForAmortizationOfGainLossBeforeTax_a5d70866-0618-4037-8f61-22c1bf21d6ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_a446b970-e385-4e3a-94c9-688bb8b3a81b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_812da138-ca99-4178-bd4f-70a8ac9eb4c6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_a446b970-e385-4e3a-94c9-688bb8b3a81b" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_812da138-ca99-4178-bd4f-70a8ac9eb4c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_ea26cac7-1cdf-4670-b077-2c12bab917a9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_a446b970-e385-4e3a-94c9-688bb8b3a81b" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_ea26cac7-1cdf-4670-b077-2c12bab917a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_2deb26ab-9c9e-4fa5-a78e-6e482c645bfc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_74666532-7ee2-4e4e-9a37-e8822053261e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_2deb26ab-9c9e-4fa5-a78e-6e482c645bfc" xlink:to="loc_us-gaap_NetIncomeLoss_74666532-7ee2-4e4e-9a37-e8822053261e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_95758f5d-8355-45b7-add1-8ca4bd5def61" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_2deb26ab-9c9e-4fa5-a78e-6e482c645bfc" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_95758f5d-8355-45b7-add1-8ca4bd5def61" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited" xlink:type="simple" xlink:href="buse-20250930.xsd#CONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_31aaeb59-af62-4913-8dd3-ea352bb48645" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_31aaeb59-af62-4913-8dd3-ea352bb48645" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfDeferredLoanOriginationFeesNet_67ef8ea5-1ed2-4543-98fd-bd411de7a792" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfDeferredLoanOriginationFeesNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_AmortizationOfDeferredLoanOriginationFeesNet_67ef8ea5-1ed2-4543-98fd-bd411de7a792" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_f0b9b3c2-91e2-4241-a9c3-64d94f165d66" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOtherOperatingLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_f0b9b3c2-91e2-4241-a9c3-64d94f165d66" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfMortgageLoansHeldForSale_14e77d05-b5f1-46d3-8f11-432e0c3b2fac" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromSaleOfMortgageLoansHeldForSale"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_ProceedsFromSaleOfMortgageLoansHeldForSale_14e77d05-b5f1-46d3-8f11-432e0c3b2fac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfMortgageServicingRightsMSRs_7a5f047c-ba19-437a-bc21-4e4def07b8ae" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfMortgageServicingRightsMSRs"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_AmortizationOfMortgageServicingRightsMSRs_7a5f047c-ba19-437a-bc21-4e4def07b8ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfInvestments_683d1153-977f-44bf-bf65-40b021fbda7f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GainLossOnSaleOfInvestments"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_GainLossOnSaleOfInvestments_683d1153-977f-44bf-bf65-40b021fbda7f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_1a8afd22-cfac-44ac-ab59-b59b1d3fbcfb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_1a8afd22-cfac-44ac-ab59-b59b1d3fbcfb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_AmortizationOfDiscountOnFederalHomeLoanBankAdvances_e9890d64-d46c-415b-a422-051ffc0d9041" xlink:href="buse-20250930.xsd#buse_AmortizationOfDiscountOnFederalHomeLoanBankAdvances"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_buse_AmortizationOfDiscountOnFederalHomeLoanBankAdvances_e9890d64-d46c-415b-a422-051ffc0d9041" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_e0c42aeb-5cad-4052-ae46-2dbd7c22e1c0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_NetIncomeLoss_e0c42aeb-5cad-4052-ae46-2dbd7c22e1c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForOriginationOfMortgageLoansHeldForSale_e33ff043-b484-4fcf-921c-3ce8969c864f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsForOriginationOfMortgageLoansHeldForSale"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_PaymentsForOriginationOfMortgageLoansHeldForSale_e33ff043-b484-4fcf-921c-3ce8969c864f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_AccretionOfPremiumsAndDiscountsOnTimeDeposits_922d1b71-0efc-41e2-b9c3-f86ea8e46d99" xlink:href="buse-20250930.xsd#buse_AccretionOfPremiumsAndDiscountsOnTimeDeposits"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_buse_AccretionOfPremiumsAndDiscountsOnTimeDeposits_922d1b71-0efc-41e2-b9c3-f86ea8e46d99" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_def43045-4134-43f2-bb32-07a519013dd9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_ShareBasedCompensation_def43045-4134-43f2-bb32-07a519013dd9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_c870c15e-7a3a-46fe-b212-2745818a1953" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_c870c15e-7a3a-46fe-b212-2745818a1953" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgageServicingRightsMSRImpairmentRecovery_b7107d35-d2b3-41ff-ac1e-8e1093be2a11" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_MortgageServicingRightsMSRImpairmentRecovery"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_MortgageServicingRightsMSRImpairmentRecovery_b7107d35-d2b3-41ff-ac1e-8e1093be2a11" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_e5b99b94-bb7f-4ed7-9aa5-81ac44d2aec2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_e5b99b94-bb7f-4ed7-9aa5-81ac44d2aec2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_962f9412-273e-4751-a36f-b5386d02f601" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment"/>
    <link:calculationArc order="16" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_962f9412-273e-4751-a36f-b5386d02f601" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_GainsLossesOnSalesOfOtherRealEstateAndOtherRepossessedAssets_400bc5fd-3647-4664-9e8f-586f5cd0c07c" xlink:href="buse-20250930.xsd#buse_GainsLossesOnSalesOfOtherRealEstateAndOtherRepossessedAssets"/>
    <link:calculationArc order="17" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_buse_GainsLossesOnSalesOfOtherRealEstateAndOtherRepossessedAssets_400bc5fd-3647-4664-9e8f-586f5cd0c07c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_GainLossOnSaleOfLoansNet_6e9e5c88-31a2-4d53-aec4-f11c7918613c" xlink:href="buse-20250930.xsd#buse_GainLossOnSaleOfLoansNet"/>
    <link:calculationArc order="18" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_buse_GainLossOnSaleOfLoansNet_6e9e5c88-31a2-4d53-aec4-f11c7918613c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_a1c362a8-25f4-43ff-8622-d8966b1fb543" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="19" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_a1c362a8-25f4-43ff-8622-d8966b1fb543" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_GainLossOnSalesOfMortgageServicingRightsMSR_37684092-b2cb-4cc2-979f-c88e1519d616" xlink:href="buse-20250930.xsd#buse_GainLossOnSalesOfMortgageServicingRightsMSR"/>
    <link:calculationArc order="20" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_buse_GainLossOnSalesOfMortgageServicingRightsMSR_37684092-b2cb-4cc2-979f-c88e1519d616" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_8c665ed5-e315-4ad8-ac85-9e949174eaaf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes"/>
    <link:calculationArc order="21" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_8c665ed5-e315-4ad8-ac85-9e949174eaaf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_ProceedsFromSaleOfMortgageServicingRightsMSROperatingActivities_724c8ec3-47a0-46e3-83cf-0f7a4037631b" xlink:href="buse-20250930.xsd#buse_ProceedsFromSaleOfMortgageServicingRightsMSROperatingActivities"/>
    <link:calculationArc order="22" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_buse_ProceedsFromSaleOfMortgageServicingRightsMSROperatingActivities_724c8ec3-47a0-46e3-83cf-0f7a4037631b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LifeInsuranceCorporateOrBankOwnedChangeInValue_acfcb278-aa2f-44ff-992e-63f12f1283bc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LifeInsuranceCorporateOrBankOwnedChangeInValue"/>
    <link:calculationArc order="23" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_LifeInsuranceCorporateOrBankOwnedChangeInValue_acfcb278-aa2f-44ff-992e-63f12f1283bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestCreditLossExpenseReversal_d8546797-6d53-43e6-8a09-0817df91c689" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestCreditLossExpenseReversal"/>
    <link:calculationArc order="24" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestCreditLossExpenseReversal_d8546797-6d53-43e6-8a09-0817df91c689" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInEquitySecuritiesFvNi_fafc50c9-ac0a-4b6a-88bb-cd4278a470ea" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInEquitySecuritiesFvNi"/>
    <link:calculationArc order="25" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_IncreaseDecreaseInEquitySecuritiesFvNi_fafc50c9-ac0a-4b6a-88bb-cd4278a470ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_GainLossOnLifeInsuranceProceeds_b4afd057-8892-4dda-a280-7825e35b96e6" xlink:href="buse-20250930.xsd#buse_GainLossOnLifeInsuranceProceeds"/>
    <link:calculationArc order="26" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_buse_GainLossOnLifeInsuranceProceeds_b4afd057-8892-4dda-a280-7825e35b96e6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfRealEstate_9334f5f9-49f0-4f08-a1fc-469ef596b85e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ImpairmentOfRealEstate"/>
    <link:calculationArc order="27" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_ImpairmentOfRealEstate_9334f5f9-49f0-4f08-a1fc-469ef596b85e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseImpairmentLoss_20c4acac-7355-4b40-b05f-03241dab77dc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseImpairmentLoss"/>
    <link:calculationArc order="28" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_94278091-7430-4df9-a65c-6f527a1941b6" xlink:to="loc_us-gaap_OperatingLeaseImpairmentLoss_20c4acac-7355-4b40-b05f-03241dab77dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_b25fb187-7dc3-4503-b99a-132ee69b1d7b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividends_5a762079-b6bb-4db9-9903-182f74b61a11" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsOfDividends"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_b25fb187-7dc3-4503-b99a-132ee69b1d7b" xlink:to="loc_us-gaap_PaymentsOfDividends_5a762079-b6bb-4db9-9903-182f74b61a11" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_167fb033-33f9-4f35-aff2-780074915d28" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_b25fb187-7dc3-4503-b99a-132ee69b1d7b" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_167fb033-33f9-4f35-aff2-780074915d28" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_ProceedsFromPaymentsForStockOptionsWarrantsAndStockAppreciationRightsExercisedNet_36967aaa-3743-483a-97ae-4e4cc741b457" xlink:href="buse-20250930.xsd#buse_ProceedsFromPaymentsForStockOptionsWarrantsAndStockAppreciationRightsExercisedNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_b25fb187-7dc3-4503-b99a-132ee69b1d7b" xlink:to="loc_buse_ProceedsFromPaymentsForStockOptionsWarrantsAndStockAppreciationRightsExercisedNet_36967aaa-3743-483a-97ae-4e4cc741b457" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfOtherDebt_210896d6-bbd9-45df-b763-3006be679653" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RepaymentsOfOtherDebt"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_b25fb187-7dc3-4503-b99a-132ee69b1d7b" xlink:to="loc_us-gaap_RepaymentsOfOtherDebt_210896d6-bbd9-45df-b763-3006be679653" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeposits_da4eac2b-bd44-484c-919f-ba3ecf813ae7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInDeposits"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_b25fb187-7dc3-4503-b99a-132ee69b1d7b" xlink:to="loc_us-gaap_IncreaseDecreaseInDeposits_da4eac2b-bd44-484c-919f-ba3ecf813ae7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchaseNet_c80fbd94-c926-480d-8964-18d6f6be588a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchaseNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_b25fb187-7dc3-4503-b99a-132ee69b1d7b" xlink:to="loc_us-gaap_IncreaseDecreaseInFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchaseNet_c80fbd94-c926-480d-8964-18d6f6be588a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_d53faabe-2148-46b0-94da-d980438ae524" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_b25fb187-7dc3-4503-b99a-132ee69b1d7b" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_d53faabe-2148-46b0-94da-d980438ae524" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_331cd095-f725-4fc4-a7ae-48a3bf6ceec2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_b25fb187-7dc3-4503-b99a-132ee69b1d7b" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_331cd095-f725-4fc4-a7ae-48a3bf6ceec2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_ProceedsFromIssuanceOfTreasuryStockForEmployeeStockPurchaseProgram_3af5f64c-29e2-43f3-9ea8-8bc7eb5b9a09" xlink:href="buse-20250930.xsd#buse_ProceedsFromIssuanceOfTreasuryStockForEmployeeStockPurchaseProgram"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_b25fb187-7dc3-4503-b99a-132ee69b1d7b" xlink:to="loc_buse_ProceedsFromIssuanceOfTreasuryStockForEmployeeStockPurchaseProgram_3af5f64c-29e2-43f3-9ea8-8bc7eb5b9a09" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromOtherDebt_a61def49-8600-475c-b560-aa5ba9fac905" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromOtherDebt"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_b25fb187-7dc3-4503-b99a-132ee69b1d7b" xlink:to="loc_us-gaap_ProceedsFromOtherDebt_a61def49-8600-475c-b560-aa5ba9fac905" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_ProceedsFromRepaymentsOfShortTermDebtExcludingFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchaseNet_b83aec3f-8fc9-4d92-aae8-245b1f217030" xlink:href="buse-20250930.xsd#buse_ProceedsFromRepaymentsOfShortTermDebtExcludingFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchaseNet"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_b25fb187-7dc3-4503-b99a-132ee69b1d7b" xlink:to="loc_buse_ProceedsFromRepaymentsOfShortTermDebtExcludingFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchaseNet_b83aec3f-8fc9-4d92-aae8-245b1f217030" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_f31fe28a-b405-4844-9ad2-9955f07f1bdf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_b25fb187-7dc3-4503-b99a-132ee69b1d7b" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_f31fe28a-b405-4844-9ad2-9955f07f1bdf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8c797cf7-6b68-4167-a9ab-f0e2f9cb25c6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_NetIncreaseDecreaseInFinancingReceivablesInvestingActivities_ad70993f-89b5-4a05-bf6d-346b95992f16" xlink:href="buse-20250930.xsd#buse_NetIncreaseDecreaseInFinancingReceivablesInvestingActivities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8c797cf7-6b68-4167-a9ab-f0e2f9cb25c6" xlink:to="loc_buse_NetIncreaseDecreaseInFinancingReceivablesInvestingActivities_ad70993f-89b5-4a05-bf6d-346b95992f16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_ProceedsFromSaleOfOtherRealEstateAndOtherRepossessedAssetsIncludingCashPaymentsCollected_931524fb-cbfb-4ca9-ac0a-e9009d89fda1" xlink:href="buse-20250930.xsd#buse_ProceedsFromSaleOfOtherRealEstateAndOtherRepossessedAssetsIncludingCashPaymentsCollected"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8c797cf7-6b68-4167-a9ab-f0e2f9cb25c6" xlink:to="loc_buse_ProceedsFromSaleOfOtherRealEstateAndOtherRepossessedAssetsIncludingCashPaymentsCollected_931524fb-cbfb-4ca9-ac0a-e9009d89fda1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_PaymentsToAcquireFederalHomeLoanBankAndFederalReserveBankStock_988dd1c0-4bb0-4e9c-a9fc-25cb22d24089" xlink:href="buse-20250930.xsd#buse_PaymentsToAcquireFederalHomeLoanBankAndFederalReserveBankStock"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8c797cf7-6b68-4167-a9ab-f0e2f9cb25c6" xlink:to="loc_buse_PaymentsToAcquireFederalHomeLoanBankAndFederalReserveBankStock_988dd1c0-4bb0-4e9c-a9fc-25cb22d24089" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireEquitySecuritiesFvNi_d8671988-2208-4d9e-9f04-a794114d8b37" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireEquitySecuritiesFvNi"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8c797cf7-6b68-4167-a9ab-f0e2f9cb25c6" xlink:to="loc_us-gaap_PaymentsToAcquireEquitySecuritiesFvNi_d8671988-2208-4d9e-9f04-a794114d8b37" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_47a2b177-bfa3-4403-9cd5-461af8c31d81" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8c797cf7-6b68-4167-a9ab-f0e2f9cb25c6" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_47a2b177-bfa3-4403-9cd5-461af8c31d81" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_7969918d-dac4-40af-b711-f57c3039319b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8c797cf7-6b68-4167-a9ab-f0e2f9cb25c6" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_7969918d-dac4-40af-b711-f57c3039319b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromLifeInsurancePolicies_c8a588c5-ccad-475c-884b-010b21a4856a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromLifeInsurancePolicies"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8c797cf7-6b68-4167-a9ab-f0e2f9cb25c6" xlink:to="loc_us-gaap_ProceedsFromLifeInsurancePolicies_c8a588c5-ccad-475c-884b-010b21a4856a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_b82796e4-73e5-43fc-aeb1-cff591b2fdb9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8c797cf7-6b68-4167-a9ab-f0e2f9cb25c6" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_b82796e4-73e5-43fc-aeb1-cff591b2fdb9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_98c095da-d1f2-47f4-be64-c52f01ac8941" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8c797cf7-6b68-4167-a9ab-f0e2f9cb25c6" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_98c095da-d1f2-47f4-be64-c52f01ac8941" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_7bf59b06-7023-48d3-8cb9-bda96e022238" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8c797cf7-6b68-4167-a9ab-f0e2f9cb25c6" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_7bf59b06-7023-48d3-8cb9-bda96e022238" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities_576116a3-bd59-4471-8115-8379e6171ddd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8c797cf7-6b68-4167-a9ab-f0e2f9cb25c6" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities_576116a3-bd59-4471-8115-8379e6171ddd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_ProceedsFromRedemptionOfFederalHomeLoanBankAndFederalReserveBankStock_2de9e7fe-a0c6-4e71-81c2-1c430c0b873c" xlink:href="buse-20250930.xsd#buse_ProceedsFromRedemptionOfFederalHomeLoanBankAndFederalReserveBankStock"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8c797cf7-6b68-4167-a9ab-f0e2f9cb25c6" xlink:to="loc_buse_ProceedsFromRedemptionOfFederalHomeLoanBankAndFederalReserveBankStock_2de9e7fe-a0c6-4e71-81c2-1c430c0b873c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfEquitySecuritiesFvNi_6baa1e58-979d-423d-9020-075350cb863e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromSaleOfEquitySecuritiesFvNi"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8c797cf7-6b68-4167-a9ab-f0e2f9cb25c6" xlink:to="loc_us-gaap_ProceedsFromSaleOfEquitySecuritiesFvNi_6baa1e58-979d-423d-9020-075350cb863e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireLifeInsurancePolicies_a3307350-e1c9-4ec6-8f02-17c8b518cd35" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireLifeInsurancePolicies"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8c797cf7-6b68-4167-a9ab-f0e2f9cb25c6" xlink:to="loc_us-gaap_PaymentsToAcquireLifeInsurancePolicies_a3307350-e1c9-4ec6-8f02-17c8b518cd35" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_1aedfc8d-8f25-4fe8-87f1-6aa62f21060e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8c797cf7-6b68-4167-a9ab-f0e2f9cb25c6" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_1aedfc8d-8f25-4fe8-87f1-6aa62f21060e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_CapitalizedExpendituresForForeclosedRealEstate_ee4958b5-33b7-4318-9c1b-489de52bb1e7" xlink:href="buse-20250930.xsd#buse_CapitalizedExpendituresForForeclosedRealEstate"/>
    <link:calculationArc order="16" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8c797cf7-6b68-4167-a9ab-f0e2f9cb25c6" xlink:to="loc_buse_CapitalizedExpendituresForForeclosedRealEstate_ee4958b5-33b7-4318-9c1b-489de52bb1e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3a2fa28e-012a-45b3-b7db-95015fff26ed" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_383b3b3c-ff94-4db0-95be-6ad713800146" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3a2fa28e-012a-45b3-b7db-95015fff26ed" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_383b3b3c-ff94-4db0-95be-6ad713800146" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_4725746d-58f0-4fe7-a475-d1da33d6f8ad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3a2fa28e-012a-45b3-b7db-95015fff26ed" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_4725746d-58f0-4fe7-a475-d1da33d6f8ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_147271e3-e60f-43ca-bf33-8439c1174ac6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3a2fa28e-012a-45b3-b7db-95015fff26ed" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_147271e3-e60f-43ca-bf33-8439c1174ac6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/MERGERSANDACQUISITIONSScheduleofEstimatedAcquisitiondateFairValuesoftheAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#MERGERSANDACQUISITIONSScheduleofEstimatedAcquisitiondateFairValuesoftheAssetsAcquiredandLiabilitiesAssumedDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/MERGERSANDACQUISITIONSScheduleofEstimatedAcquisitiondateFairValuesoftheAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_b5001832-5a0e-4122-a383-358e5a0c030b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_5e73b05d-d871-48d3-b38a-d0864eb550cb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_b5001832-5a0e-4122-a383-358e5a0c030b" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_5e73b05d-d871-48d3-b38a-d0864eb550cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesFinancingReceivables_daae10be-d040-414f-9363-c597edc2dd91" xlink:href="buse-20250930.xsd#buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesFinancingReceivables"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_b5001832-5a0e-4122-a383-358e5a0c030b" xlink:to="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesFinancingReceivables_daae10be-d040-414f-9363-c597edc2dd91" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_19e6345c-4274-4923-a1f0-19d42a3314ca" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_b5001832-5a0e-4122-a383-358e5a0c030b" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_19e6345c-4274-4923-a1f0-19d42a3314ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_082f7f28-182e-404d-8d5c-ea63896e70f1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_b5001832-5a0e-4122-a383-358e5a0c030b" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_082f7f28-182e-404d-8d5c-ea63896e70f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssets_3a2392f1-ecfe-469b-9c46-44f29ad32a71" xlink:href="buse-20250930.xsd#buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_b5001832-5a0e-4122-a383-358e5a0c030b" xlink:to="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssets_3a2392f1-ecfe-469b-9c46-44f29ad32a71" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedSecuritiesAvailableForSale_9f223e66-d94b-4953-b531-c8b8f846cd65" xlink:href="buse-20250930.xsd#buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedSecuritiesAvailableForSale"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_b5001832-5a0e-4122-a383-358e5a0c030b" xlink:to="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedSecuritiesAvailableForSale_9f223e66-d94b-4953-b531-c8b8f846cd65" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_0150162f-c5a1-43ef-86e6-203d7e295a1d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_ed4e43dc-6d09-4508-8170-4ede15e27ce9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_0150162f-c5a1-43ef-86e6-203d7e295a1d" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_ed4e43dc-6d09-4508-8170-4ede15e27ce9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_23f3521a-db3d-47da-8ddb-e9ec06430d74" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_0150162f-c5a1-43ef-86e6-203d7e295a1d" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_23f3521a-db3d-47da-8ddb-e9ec06430d74" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_d336122d-ebba-40ae-834e-ad6ab55189f4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesJuniorSubordinatedNotes_5732074c-ddfb-415c-b503-54bb9b59b5f1" xlink:href="buse-20250930.xsd#buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesJuniorSubordinatedNotes"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_d336122d-ebba-40ae-834e-ad6ab55189f4" xlink:to="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesJuniorSubordinatedNotes_5732074c-ddfb-415c-b503-54bb9b59b5f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesSubordinatedNotesNet_ffbf0f51-c5ea-4501-8b43-73f10c24f8d2" xlink:href="buse-20250930.xsd#buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesSubordinatedNotesNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_d336122d-ebba-40ae-834e-ad6ab55189f4" xlink:to="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesSubordinatedNotesNet_ffbf0f51-c5ea-4501-8b43-73f10c24f8d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedShortTermDebt_2cafb33f-db42-4015-82df-6f4b2e5f59b1" xlink:href="buse-20250930.xsd#buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedShortTermDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_d336122d-ebba-40ae-834e-ad6ab55189f4" xlink:to="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedShortTermDebt_2cafb33f-db42-4015-82df-6f4b2e5f59b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeposits_4aa62332-c278-4876-ac50-6a5585fb98c9" xlink:href="buse-20250930.xsd#buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeposits"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_d336122d-ebba-40ae-834e-ad6ab55189f4" xlink:to="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeposits_4aa62332-c278-4876-ac50-6a5585fb98c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherLiabilities_0af2438c-89d9-4698-8e73-5f17139af310" xlink:href="buse-20250930.xsd#buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_d336122d-ebba-40ae-834e-ad6ab55189f4" xlink:to="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherLiabilities_0af2438c-89d9-4698-8e73-5f17139af310" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebtExcludingSubordinatedNotes_25667732-f167-49a7-b178-25d5d096e0b1" xlink:href="buse-20250930.xsd#buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebtExcludingSubordinatedNotes"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_d336122d-ebba-40ae-834e-ad6ab55189f4" xlink:to="loc_buse_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebtExcludingSubordinatedNotes_25667732-f167-49a7-b178-25d5d096e0b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_caa0b231-a7f9-4e5c-b2c3-30c15fefd54e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_PaymentsToAcquireBusinessGrossAndOtherConsiderationTransferred_f236370a-db52-48ef-9733-054f9bb6159c" xlink:href="buse-20250930.xsd#buse_PaymentsToAcquireBusinessGrossAndOtherConsiderationTransferred"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_caa0b231-a7f9-4e5c-b2c3-30c15fefd54e" xlink:to="loc_buse_PaymentsToAcquireBusinessGrossAndOtherConsiderationTransferred_f236370a-db52-48ef-9733-054f9bb6159c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_6ebde843-8ce5-4b27-a7c3-3849f704f258" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_caa0b231-a7f9-4e5c-b2c3-30c15fefd54e" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_6ebde843-8ce5-4b27-a7c3-3849f704f258" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/MERGERSANDACQUISITIONSScheduleofReconciliationBetweenthePurchasePriceandtheFairValueDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#MERGERSANDACQUISITIONSScheduleofReconciliationBetweenthePurchasePriceandtheFairValueDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/MERGERSANDACQUISITIONSScheduleofReconciliationBetweenthePurchasePriceandtheFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinancialAssets_f2955d98-49f9-4c30-9367-b369dfdb56e6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinancialAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAcquiredReceivablesGrossContractualAmount_d8e7c1e5-8855-49a1-8ad7-4bd2ce129c2d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationAcquiredReceivablesGrossContractualAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinancialAssets_f2955d98-49f9-4c30-9367-b369dfdb56e6" xlink:to="loc_us-gaap_BusinessCombinationAcquiredReceivablesGrossContractualAmount_d8e7c1e5-8855-49a1-8ad7-4bd2ce129c2d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAcquiredReceivablesEstimatedUncollectible_c65d3394-a970-4c4e-8bc3-5fa66b5fd3ed" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationAcquiredReceivablesEstimatedUncollectible"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinancialAssets_f2955d98-49f9-4c30-9367-b369dfdb56e6" xlink:to="loc_us-gaap_BusinessCombinationAcquiredReceivablesEstimatedUncollectible_c65d3394-a970-4c4e-8bc3-5fa66b5fd3ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationInterestPremiumDiscountSpecificToPCDFinancialAssets_76016513-23ec-4585-a9a2-91367ea6a32d" xlink:href="buse-20250930.xsd#buse_BusinessCombinationInterestPremiumDiscountSpecificToPCDFinancialAssets"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinancialAssets_f2955d98-49f9-4c30-9367-b369dfdb56e6" xlink:to="loc_buse_BusinessCombinationInterestPremiumDiscountSpecificToPCDFinancialAssets_76016513-23ec-4585-a9a2-91367ea6a32d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_BusinessCombinationLoansPreviouslyChargedOff_59d00ad7-2ac2-460e-9ace-5370e10061ee" xlink:href="buse-20250930.xsd#buse_BusinessCombinationLoansPreviouslyChargedOff"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinancialAssets_f2955d98-49f9-4c30-9367-b369dfdb56e6" xlink:to="loc_buse_BusinessCombinationLoansPreviouslyChargedOff_59d00ad7-2ac2-460e-9ace-5370e10061ee" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/DEBTSECURITIESScheduleofAmortizedCostUnrealizedorUnrecognizedGainsandLossesandFairValuesofSecuritiesClassifiedasAFSandHTMDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#DEBTSECURITIESScheduleofAmortizedCostUnrealizedorUnrecognizedGainsandLossesandFairValuesofSecuritiesClassifiedasAFSandHTMDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/DEBTSECURITIESScheduleofAmortizedCostUnrealizedorUnrecognizedGainsandLossesandFairValuesofSecuritiesClassifiedasAFSandHTMDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_41b23057-0716-4d37-bf6a-e4af6bd0f5d4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss_b0ce67d3-ae9a-4c3d-8ff2-391f0827dcac" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_41b23057-0716-4d37-bf6a-e4af6bd0f5d4" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss_b0ce67d3-ae9a-4c3d-8ff2-391f0827dcac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesFairValue_c843dfde-9687-4b05-85a9-3306c92a72c6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_41b23057-0716-4d37-bf6a-e4af6bd0f5d4" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesFairValue_c843dfde-9687-4b05-85a9-3306c92a72c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain_b1afdcaf-9e14-4169-9a73-c15fb4854ee2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_41b23057-0716-4d37-bf6a-e4af6bd0f5d4" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain_b1afdcaf-9e14-4169-9a73-c15fb4854ee2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_2742c86e-0ffa-46f4-9952-391bdf4361f2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_0809cea0-170d-4da8-844b-4d3a780feda5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_2742c86e-0ffa-46f4-9952-391bdf4361f2" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_0809cea0-170d-4da8-844b-4d3a780feda5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_a3a62b5b-adb7-4dc2-afd5-dcd477611e32" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_2742c86e-0ffa-46f4-9952-391bdf4361f2" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_a3a62b5b-adb7-4dc2-afd5-dcd477611e32" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_f6c2350e-5a04-496f-b39b-551a3e15227e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_2742c86e-0ffa-46f4-9952-391bdf4361f2" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_f6c2350e-5a04-496f-b39b-551a3e15227e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/DEBTSECURITIESScheduleofMaturityofDebtSecuritiesDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#DEBTSECURITIESScheduleofMaturityofDebtSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/DEBTSECURITIESScheduleofMaturityofDebtSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_7219e0b8-8182-450a-a893-35f0f2cb6a33" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsAmortizedCostBasis_894c4e50-4ca8-416b-81c5-ed957f0f2ddd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsAmortizedCostBasis"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_7219e0b8-8182-450a-a893-35f0f2cb6a33" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsAmortizedCostBasis_894c4e50-4ca8-416b-81c5-ed957f0f2ddd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenAmortizedCostBasis_4ebdae4f-e9cf-495d-a720-96ffd54f6374" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenAmortizedCostBasis"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_7219e0b8-8182-450a-a893-35f0f2cb6a33" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenAmortizedCostBasis_4ebdae4f-e9cf-495d-a720-96ffd54f6374" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenAmortizedCostBasis_3d049bb7-5d31-43db-bc34-fbc02deb2d42" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenAmortizedCostBasis"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_7219e0b8-8182-450a-a893-35f0f2cb6a33" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenAmortizedCostBasis_3d049bb7-5d31-43db-bc34-fbc02deb2d42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveAmortizedCostBasis_c60b6cca-31cf-44b1-8780-00688cde60b2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveAmortizedCostBasis"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_7219e0b8-8182-450a-a893-35f0f2cb6a33" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveAmortizedCostBasis_c60b6cca-31cf-44b1-8780-00688cde60b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_7357fa17-4348-426f-8396-18f76931cd4b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue_5a8c1f7f-79be-4167-9b0a-7a0061bfc4ea" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_7357fa17-4348-426f-8396-18f76931cd4b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue_5a8c1f7f-79be-4167-9b0a-7a0061bfc4ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue_f17135de-dd1c-4169-b5a4-92a25e9c0aed" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_7357fa17-4348-426f-8396-18f76931cd4b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue_f17135de-dd1c-4169-b5a4-92a25e9c0aed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue_684cae12-2669-4a3c-80b3-195e31a71668" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_7357fa17-4348-426f-8396-18f76931cd4b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue_684cae12-2669-4a3c-80b3-195e31a71668" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenFairValue_a17a6cac-5fa1-474a-9cbe-3e66c7df38a5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenFairValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_7357fa17-4348-426f-8396-18f76931cd4b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenFairValue_a17a6cac-5fa1-474a-9cbe-3e66c7df38a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesFairValue_55e77c8c-7c0f-49c9-ab83-9fc7c357dd13" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_ff28307e-bc1c-4e3a-9461-2769e3394524" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesFairValue_55e77c8c-7c0f-49c9-ab83-9fc7c357dd13" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_ff28307e-bc1c-4e3a-9461-2769e3394524" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue_9c1882dc-1c0d-4f47-b8ad-c1edbcdf6e71" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesFairValue_55e77c8c-7c0f-49c9-ab83-9fc7c357dd13" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue_9c1882dc-1c0d-4f47-b8ad-c1edbcdf6e71" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_f4dcf939-db78-486c-8ba6-caa2b3169b30" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesFairValue_55e77c8c-7c0f-49c9-ab83-9fc7c357dd13" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_f4dcf939-db78-486c-8ba6-caa2b3169b30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsFairValue_adebbd68-2083-43cb-b0b5-8a896462e9c9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsFairValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesFairValue_55e77c8c-7c0f-49c9-ab83-9fc7c357dd13" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsFairValue_adebbd68-2083-43cb-b0b5-8a896462e9c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_b71b9e91-074b-4e8d-89db-0e1991dda8c1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateAfterYear5Through10_0306b48f-2ec8-4d04-965e-4d13cf2c9330" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateAfterYear5Through10"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_b71b9e91-074b-4e8d-89db-0e1991dda8c1" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateAfterYear5Through10_0306b48f-2ec8-4d04-965e-4d13cf2c9330" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughFive_2c0431b2-c3c8-414b-9f17-0e7d59b72e16" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughFive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_b71b9e91-074b-4e8d-89db-0e1991dda8c1" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughFive_2c0431b2-c3c8-414b-9f17-0e7d59b72e16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateYearOne_58f2427c-36b1-4f5c-869c-0c56ef487dfc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateYearOne"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_b71b9e91-074b-4e8d-89db-0e1991dda8c1" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateYearOne_58f2427c-36b1-4f5c-869c-0c56ef487dfc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateAfterYear10_725937fa-8386-424d-b5a1-883c8ce20011" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateAfterYear10"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_b71b9e91-074b-4e8d-89db-0e1991dda8c1" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossMaturityAllocatedAndSingleMaturityDateAfterYear10_725937fa-8386-424d-b5a1-883c8ce20011" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/DEBTSECURITIESScheduleofRealizedGainsandLossesonDebtSecuritiesDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#DEBTSECURITIESScheduleofRealizedGainsandLossesonDebtSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/DEBTSECURITIESScheduleofRealizedGainsandLossesonDebtSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss_fd4f5abc-0b5b-454c-8274-733ecbc5f867" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss_5d966843-72b8-4282-bc18-92602b71a11a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss_fd4f5abc-0b5b-454c-8274-733ecbc5f867" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss_5d966843-72b8-4282-bc18-92602b71a11a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGain_aceebbfe-9b5f-4e78-8ccd-a0b97270f0f8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedGain"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss_fd4f5abc-0b5b-454c-8274-733ecbc5f867" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGain_aceebbfe-9b5f-4e78-8ccd-a0b97270f0f8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/DEBTSECURITIESScheduleofDebtSecuritiesinanUnrealizedorUnrecognizedLossPositionDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#DEBTSECURITIESScheduleofDebtSecuritiesinanUnrealizedorUnrecognizedLossPositionDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/DEBTSECURITIESScheduleofDebtSecuritiesinanUnrealizedorUnrecognizedLossPositionDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionAccumulatedLoss_595eb539-8191-4fb1-8cf8-9e227f363f6b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionAccumulatedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_169b26a2-9c05-4655-a3e7-3580cb1b33d0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionAccumulatedLoss_595eb539-8191-4fb1-8cf8-9e227f363f6b" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_169b26a2-9c05-4655-a3e7-3580cb1b33d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_ff043a59-ffca-4556-8cc6-810f9990e575" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_4e7fc1c5-20f2-4bcb-b763-35726be25cfc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_ff043a59-ffca-4556-8cc6-810f9990e575" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_4e7fc1c5-20f2-4bcb-b763-35726be25cfc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_72e6df1b-734c-42db-9c6b-6f962de91f30" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_ff043a59-ffca-4556-8cc6-810f9990e575" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_72e6df1b-734c-42db-9c6b-6f962de91f30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionFairValue_a15a049f-7e85-4666-b5a6-f61ad01979f7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_e778a911-a60b-4f4b-8dc5-5d3e11a1fdb5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionFairValue_a15a049f-7e85-4666-b5a6-f61ad01979f7" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_e778a911-a60b-4f4b-8dc5-5d3e11a1fdb5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_e711724e-60b6-47bb-b64c-3c5e13df7fea" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_2edbb20e-40b0-4584-a9df-3e9a60095345" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_e711724e-60b6-47bb-b64c-3c5e13df7fea" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_2edbb20e-40b0-4584-a9df-3e9a60095345" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_9bfb3101-9255-48c8-835b-e5a5d4bae355" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_e711724e-60b6-47bb-b64c-3c5e13df7fea" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_9bfb3101-9255-48c8-835b-e5a5d4bae355" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/DEBTSECURITIESScheduleofAdditionalInformationonDebtSecuritiesInUnrealizedorUnrecognizedLossPositionDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#DEBTSECURITIESScheduleofAdditionalInformationonDebtSecuritiesInUnrealizedorUnrecognizedLossPositionDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/DEBTSECURITIESScheduleofAdditionalInformationonDebtSecuritiesInUnrealizedorUnrecognizedLossPositionDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_buse_DebtSecuritiesFairValue_fe143a15-8ddd-4414-bdfd-466508baf6b7" xlink:href="buse-20250930.xsd#buse_DebtSecuritiesFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionFairValue_fced7522-fd6c-4817-a771-48dcd8ff46b9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_buse_DebtSecuritiesFairValue_fe143a15-8ddd-4414-bdfd-466508baf6b7" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionFairValue_fced7522-fd6c-4817-a771-48dcd8ff46b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_4c487e4a-3131-44b4-bb67-032233527081" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_buse_DebtSecuritiesFairValue_fe143a15-8ddd-4414-bdfd-466508baf6b7" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_4c487e4a-3131-44b4-bb67-032233527081" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_TotalCountOfDebtSecurities_20cff285-1186-4702-a607-4408e8486ec1" xlink:href="buse-20250930.xsd#buse_TotalCountOfDebtSecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_TotalCountOfDebtSecuritiesAvailableForSaleSecurities_c752da4d-560e-4417-a9a8-8c263a97646d" xlink:href="buse-20250930.xsd#buse_TotalCountOfDebtSecuritiesAvailableForSaleSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_buse_TotalCountOfDebtSecurities_20cff285-1186-4702-a607-4408e8486ec1" xlink:to="loc_buse_TotalCountOfDebtSecuritiesAvailableForSaleSecurities_c752da4d-560e-4417-a9a8-8c263a97646d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_TotalCountOfDebtSecuritiesHeldToMaturity_faf77b81-26ed-47d5-b5cb-f182d0054f01" xlink:href="buse-20250930.xsd#buse_TotalCountOfDebtSecuritiesHeldToMaturity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_buse_TotalCountOfDebtSecurities_20cff285-1186-4702-a607-4408e8486ec1" xlink:to="loc_buse_TotalCountOfDebtSecuritiesHeldToMaturity_faf77b81-26ed-47d5-b5cb-f182d0054f01" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_DebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_52c39ad1-3a48-40ea-b876-301ac8c9778b" xlink:href="buse-20250930.xsd#buse_DebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_803185d2-ce8f-471a-b68e-ec33d49ac9bf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_buse_DebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_52c39ad1-3a48-40ea-b876-301ac8c9778b" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_803185d2-ce8f-471a-b68e-ec33d49ac9bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionAccumulatedLoss_30fe557e-8c4c-4e35-9caa-d475acd8155a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionAccumulatedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_buse_DebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_52c39ad1-3a48-40ea-b876-301ac8c9778b" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionAccumulatedLoss_30fe557e-8c4c-4e35-9caa-d475acd8155a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_DebtSecuritiesUnrealizedLossPositionNumberOfPositions_46f32627-a8c8-4cb9-a58d-8a981c18fa09" xlink:href="buse-20250930.xsd#buse_DebtSecuritiesUnrealizedLossPositionNumberOfPositions"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionNumberOfPositions_eba89739-772c-43ea-885b-e86bec840db9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionNumberOfPositions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_buse_DebtSecuritiesUnrealizedLossPositionNumberOfPositions_46f32627-a8c8-4cb9-a58d-8a981c18fa09" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionNumberOfPositions_eba89739-772c-43ea-885b-e86bec840db9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_DebtSecuritiesHeldToMaturityUnrealizedLossPositionNumberOfPositions_0e8852a2-e832-47c8-9fc5-82e1dff45a07" xlink:href="buse-20250930.xsd#buse_DebtSecuritiesHeldToMaturityUnrealizedLossPositionNumberOfPositions"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_buse_DebtSecuritiesUnrealizedLossPositionNumberOfPositions_46f32627-a8c8-4cb9-a58d-8a981c18fa09" xlink:to="loc_buse_DebtSecuritiesHeldToMaturityUnrealizedLossPositionNumberOfPositions_0e8852a2-e832-47c8-9fc5-82e1dff45a07" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/PORTFOLIOLOANSScheduleofDistributionofPortfolioLoansDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#PORTFOLIOLOANSScheduleofDistributionofPortfolioLoansDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/PORTFOLIOLOANSScheduleofDistributionofPortfolioLoansDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_e8cdb6d0-139a-4825-9c7b-c4d2a353579d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest_16d44ffd-a901-4444-9465-83b4addd42ac" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_e8cdb6d0-139a-4825-9c7b-c4d2a353579d" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest_16d44ffd-a901-4444-9465-83b4addd42ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_9dca73c1-2f65-4c19-8f9a-b3bfe3e104c8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_e8cdb6d0-139a-4825-9c7b-c4d2a353579d" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_9dca73c1-2f65-4c19-8f9a-b3bfe3e104c8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/PORTFOLIOLOANSScheduleofRiskGradesofPortfolioLoansFurtherSortedbyOriginationDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#PORTFOLIOLOANSScheduleofRiskGradesofPortfolioLoansFurtherSortedbyOriginationDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/PORTFOLIOLOANSScheduleofRiskGradesofPortfolioLoansFurtherSortedbyOriginationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_buse_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLossWriteoff_c48294d1-9057-4816-98ad-59d3eb5c3c4e" xlink:href="buse-20250930.xsd#buse_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLossWriteoff"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestRevolvingWriteoff_a0473fc2-2c5c-4785-9cdd-90218ef21a1d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestRevolvingWriteoff"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_buse_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLossWriteoff_c48294d1-9057-4816-98ad-59d3eb5c3c4e" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestRevolvingWriteoff_a0473fc2-2c5c-4785-9cdd-90218ef21a1d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearThreeOriginatedTwoYearsBeforeCurrentFiscalYearWriteoff_b8a6dd16-ff51-4a58-a6fb-c028da566dbd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearThreeOriginatedTwoYearsBeforeCurrentFiscalYearWriteoff"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_buse_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLossWriteoff_c48294d1-9057-4816-98ad-59d3eb5c3c4e" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearThreeOriginatedTwoYearsBeforeCurrentFiscalYearWriteoff_b8a6dd16-ff51-4a58-a6fb-c028da566dbd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFourOriginatedThreeYearsBeforeCurrentFiscalYearWriteoff_0ddaaca7-5a41-43cd-9411-30438a43c694" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearFourOriginatedThreeYearsBeforeCurrentFiscalYearWriteoff"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_buse_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLossWriteoff_c48294d1-9057-4816-98ad-59d3eb5c3c4e" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFourOriginatedThreeYearsBeforeCurrentFiscalYearWriteoff_0ddaaca7-5a41-43cd-9411-30438a43c694" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestOriginatedMoreThanFiveYearsBeforeCurrentFiscalYearWriteoff_a7489483-fa9d-4b8b-9961-b1f2d0932793" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestOriginatedMoreThanFiveYearsBeforeCurrentFiscalYearWriteoff"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_buse_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLossWriteoff_c48294d1-9057-4816-98ad-59d3eb5c3c4e" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestOriginatedMoreThanFiveYearsBeforeCurrentFiscalYearWriteoff_a7489483-fa9d-4b8b-9961-b1f2d0932793" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFiveOriginatedFourYearsBeforeCurrentFiscalYearWriteoff_4df20404-0dd8-4476-970f-97ee50446d77" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearFiveOriginatedFourYearsBeforeCurrentFiscalYearWriteoff"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_buse_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLossWriteoff_c48294d1-9057-4816-98ad-59d3eb5c3c4e" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFiveOriginatedFourYearsBeforeCurrentFiscalYearWriteoff_4df20404-0dd8-4476-970f-97ee50446d77" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearOneOriginatedCurrentFiscalYearWriteoff_d4490519-c6cd-4925-9b01-0d67869010ab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearOneOriginatedCurrentFiscalYearWriteoff"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_buse_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLossWriteoff_c48294d1-9057-4816-98ad-59d3eb5c3c4e" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearOneOriginatedCurrentFiscalYearWriteoff_d4490519-c6cd-4925-9b01-0d67869010ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearTwoOriginatedFiscalYearBeforeCurrentFiscalYearWriteoff_176a0d1b-d76f-4192-98ce-826cb698786c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearTwoOriginatedFiscalYearBeforeCurrentFiscalYearWriteoff"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_buse_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLossWriteoff_c48294d1-9057-4816-98ad-59d3eb5c3c4e" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearTwoOriginatedFiscalYearBeforeCurrentFiscalYearWriteoff_176a0d1b-d76f-4192-98ce-826cb698786c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_fdf02517-7972-4db1-91f4-3e3e9f00f1bb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearOneOriginatedCurrentFiscalYear_067420f9-0938-41d6-b811-b13ea5088365" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearOneOriginatedCurrentFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_fdf02517-7972-4db1-91f4-3e3e9f00f1bb" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearOneOriginatedCurrentFiscalYear_067420f9-0938-41d6-b811-b13ea5088365" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearTwoOriginatedFiscalYearBeforeCurrentFiscalYear_1d6acd74-e7a3-4449-89c3-7aaf68c9a913" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearTwoOriginatedFiscalYearBeforeCurrentFiscalYear"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_fdf02517-7972-4db1-91f4-3e3e9f00f1bb" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearTwoOriginatedFiscalYearBeforeCurrentFiscalYear_1d6acd74-e7a3-4449-89c3-7aaf68c9a913" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearThreeOriginatedTwoYearsBeforeCurrentFiscalYear_52d8bc91-d51b-4483-ba89-f8ed2a7c5cf2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearThreeOriginatedTwoYearsBeforeCurrentFiscalYear"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_fdf02517-7972-4db1-91f4-3e3e9f00f1bb" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearThreeOriginatedTwoYearsBeforeCurrentFiscalYear_52d8bc91-d51b-4483-ba89-f8ed2a7c5cf2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFourOriginatedThreeYearsBeforeCurrentFiscalYear_b758ac3a-db6e-43c1-ada3-f34ba276cb8a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearFourOriginatedThreeYearsBeforeCurrentFiscalYear"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_fdf02517-7972-4db1-91f4-3e3e9f00f1bb" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFourOriginatedThreeYearsBeforeCurrentFiscalYear_b758ac3a-db6e-43c1-ada3-f34ba276cb8a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFiveOriginatedFourYearsBeforeCurrentFiscalYear_48171cf5-af89-45d3-b45d-141992226e54" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearFiveOriginatedFourYearsBeforeCurrentFiscalYear"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_fdf02517-7972-4db1-91f4-3e3e9f00f1bb" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFiveOriginatedFourYearsBeforeCurrentFiscalYear_48171cf5-af89-45d3-b45d-141992226e54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestOriginatedMoreThanFiveYearsBeforeCurrentFiscalYear_ee62864b-c208-46e1-aee7-b4120aa2d017" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestOriginatedMoreThanFiveYearsBeforeCurrentFiscalYear"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_fdf02517-7972-4db1-91f4-3e3e9f00f1bb" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestOriginatedMoreThanFiveYearsBeforeCurrentFiscalYear_ee62864b-c208-46e1-aee7-b4120aa2d017" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestRevolving_37a81e9c-f434-447a-a220-f5c1bd995d95" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestRevolving"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_fdf02517-7972-4db1-91f4-3e3e9f00f1bb" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestRevolving_37a81e9c-f434-447a-a220-f5c1bd995d95" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/LEASESScheduleofLeaseRelatedBalancesDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#LEASESScheduleofLeaseRelatedBalancesDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/LEASESScheduleofLeaseRelatedBalancesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_buse_LeasesLiability_765e4657-ea9e-473e-a9d3-56cf2eb8713e" xlink:href="buse-20250930.xsd#buse_LeasesLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_306734c9-8771-4290-872b-6715be4ff4ad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_buse_LeasesLiability_765e4657-ea9e-473e-a9d3-56cf2eb8713e" xlink:to="loc_us-gaap_OperatingLeaseLiability_306734c9-8771-4290-872b-6715be4ff4ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_129911a7-5984-4c51-aa15-e27a968b2ec4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_buse_LeasesLiability_765e4657-ea9e-473e-a9d3-56cf2eb8713e" xlink:to="loc_us-gaap_FinanceLeaseLiability_129911a7-5984-4c51-aa15-e27a968b2ec4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_LeasesRightOfUseAsset_0d10fe7a-127c-4ddd-bbd5-bccd96deef05" xlink:href="buse-20250930.xsd#buse_LeasesRightOfUseAsset"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_09fb38b5-68ef-4586-8d83-d348f34ef991" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_buse_LeasesRightOfUseAsset_0d10fe7a-127c-4ddd-bbd5-bccd96deef05" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_09fb38b5-68ef-4586-8d83-d348f34ef991" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_d799e778-da8c-442c-95b1-ea72707aa6c2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseRightOfUseAsset"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_buse_LeasesRightOfUseAsset_0d10fe7a-127c-4ddd-bbd5-bccd96deef05" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAsset_d799e778-da8c-442c-95b1-ea72707aa6c2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/LEASESScheduleofLeaseCostsandOtherLeaseInformationDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#LEASESScheduleofLeaseCostsandOtherLeaseInformationDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/LEASESScheduleofLeaseCostsandOtherLeaseInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_e6c5a826-57b2-49d6-814e-28105950689f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermLeaseCost_83b4d1cf-84a3-410f-ba0a-34932a826e1f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermLeaseCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_e6c5a826-57b2-49d6-814e-28105950689f" xlink:to="loc_us-gaap_ShortTermLeaseCost_83b4d1cf-84a3-410f-ba0a-34932a826e1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableLeaseCost_5c32e5bc-8f71-4f77-b55f-be2ea2a937a3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_VariableLeaseCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_e6c5a826-57b2-49d6-814e-28105950689f" xlink:to="loc_us-gaap_VariableLeaseCost_5c32e5bc-8f71-4f77-b55f-be2ea2a937a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_bf7376b3-c129-4d2b-bdb6-8f4caac0229a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_e6c5a826-57b2-49d6-814e-28105950689f" xlink:to="loc_us-gaap_OperatingLeaseCost_bf7376b3-c129-4d2b-bdb6-8f4caac0229a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseInterestExpense_1a306fa5-1438-447b-8fa0-cec974b8ee10" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseInterestExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_e6c5a826-57b2-49d6-814e-28105950689f" xlink:to="loc_us-gaap_FinanceLeaseInterestExpense_1a306fa5-1438-447b-8fa0-cec974b8ee10" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_aa3f19d0-5ba3-418d-b3e6-539fa8dda28f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseRightOfUseAssetAmortization"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_e6c5a826-57b2-49d6-814e-28105950689f" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_aa3f19d0-5ba3-418d-b3e6-539fa8dda28f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/LEASESScheduleofFutureUndiscountedLeasePaymentsDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#LEASESScheduleofFutureUndiscountedLeasePaymentsDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/LEASESScheduleofFutureUndiscountedLeasePaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_575b58eb-1ac4-43cc-8a5d-b02ed3d4d87d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_9b03f669-6540-4a34-b2f0-cb255a339729" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_575b58eb-1ac4-43cc-8a5d-b02ed3d4d87d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_9b03f669-6540-4a34-b2f0-cb255a339729" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_78040f33-a21a-4c24-9af5-0c83094ceaa8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_575b58eb-1ac4-43cc-8a5d-b02ed3d4d87d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_78040f33-a21a-4c24-9af5-0c83094ceaa8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_3ba60b3d-782e-4b7e-bf68-da20f0d1281a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_575b58eb-1ac4-43cc-8a5d-b02ed3d4d87d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_3ba60b3d-782e-4b7e-bf68-da20f0d1281a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_1e5bde97-ac98-47f7-80ff-ffd4a9cbd908" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_575b58eb-1ac4-43cc-8a5d-b02ed3d4d87d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_1e5bde97-ac98-47f7-80ff-ffd4a9cbd908" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_a5299009-a999-4d8f-b8b0-1b73e9fbedc5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_575b58eb-1ac4-43cc-8a5d-b02ed3d4d87d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_a5299009-a999-4d8f-b8b0-1b73e9fbedc5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_5b8d6749-d7f2-41cb-9240-40c4ba6ed609" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_575b58eb-1ac4-43cc-8a5d-b02ed3d4d87d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_5b8d6749-d7f2-41cb-9240-40c4ba6ed609" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_a2975d8b-9ca5-45e2-b4aa-790f80a3da13" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_575b58eb-1ac4-43cc-8a5d-b02ed3d4d87d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_a2975d8b-9ca5-45e2-b4aa-790f80a3da13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_93f29dbf-7393-44c1-ba8d-cb2f8d9eaa29" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsRemainderOfFiscalYear_12849cad-4277-4fe8-98ce-83c07ee86117" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_93f29dbf-7393-44c1-ba8d-cb2f8d9eaa29" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsRemainderOfFiscalYear_12849cad-4277-4fe8-98ce-83c07ee86117" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_614778c8-6f15-410d-86ad-454907d6dee6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_93f29dbf-7393-44c1-ba8d-cb2f8d9eaa29" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_614778c8-6f15-410d-86ad-454907d6dee6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_4e7f7401-c1db-48c2-bda8-92c595b2cee1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_93f29dbf-7393-44c1-ba8d-cb2f8d9eaa29" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_4e7f7401-c1db-48c2-bda8-92c595b2cee1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_872b0237-9114-47cd-bae4-4eca74f5cdad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_93f29dbf-7393-44c1-ba8d-cb2f8d9eaa29" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_872b0237-9114-47cd-bae4-4eca74f5cdad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_c0779315-383a-4a3d-9a86-4e40ee82d903" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_93f29dbf-7393-44c1-ba8d-cb2f8d9eaa29" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_c0779315-383a-4a3d-9a86-4e40ee82d903" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive_e272c84b-885b-4b5e-bbbf-1e7723e186a6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_93f29dbf-7393-44c1-ba8d-cb2f8d9eaa29" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive_e272c84b-885b-4b5e-bbbf-1e7723e186a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive_51e42df5-4435-4f77-ae77-aaca72c1ead0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_93f29dbf-7393-44c1-ba8d-cb2f8d9eaa29" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive_51e42df5-4435-4f77-ae77-aaca72c1ead0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/LEASESScheduleofFutureUndiscountedLeasePaymentsDetails_1" xlink:type="simple" xlink:href="buse-20250930.xsd#LEASESScheduleofFutureUndiscountedLeasePaymentsDetails_1"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/LEASESScheduleofFutureUndiscountedLeasePaymentsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_675dce86-bc5e-4a9f-959f-21563adcdd81" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_173be215-b0d6-4575-b6a1-1fca551bd205" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_675dce86-bc5e-4a9f-959f-21563adcdd81" xlink:to="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_173be215-b0d6-4575-b6a1-1fca551bd205" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_8eb48764-de59-4a34-8373-8bdcc91f09ea" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_675dce86-bc5e-4a9f-959f-21563adcdd81" xlink:to="loc_us-gaap_FinanceLeaseLiability_8eb48764-de59-4a34-8373-8bdcc91f09ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_4f7c24d9-00dc-41c0-b85b-8e40bc64910c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_8b1cfea3-d233-4d2e-b033-14055e55ff5f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_4f7c24d9-00dc-41c0-b85b-8e40bc64910c" xlink:to="loc_us-gaap_OperatingLeaseLiability_8b1cfea3-d233-4d2e-b033-14055e55ff5f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_970e8a91-59d1-4a7c-9df1-f8d88aed34ea" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_4f7c24d9-00dc-41c0-b85b-8e40bc64910c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_970e8a91-59d1-4a7c-9df1-f8d88aed34ea" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/LEASESScheduleofFutureMinimumLeasePaymentsDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#LEASESScheduleofFutureMinimumLeasePaymentsDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/LEASESScheduleofFutureMinimumLeasePaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_ce96f4fe-b3cb-43f6-83d6-e52e5ea71bbf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceived"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedFourYears_f512c5c9-189b-49ed-9d00-4e363acf8270" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedFourYears"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_ce96f4fe-b3cb-43f6-83d6-e52e5ea71bbf" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedFourYears_f512c5c9-189b-49ed-9d00-4e363acf8270" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedRemainderOfFiscalYear_bd8f0eb7-0856-4a23-af3e-14f2ae680410" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedRemainderOfFiscalYear"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_ce96f4fe-b3cb-43f6-83d6-e52e5ea71bbf" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedRemainderOfFiscalYear_bd8f0eb7-0856-4a23-af3e-14f2ae680410" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedThreeYears_057e8bb2-0913-498d-a648-d3356ea57abb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedThreeYears"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_ce96f4fe-b3cb-43f6-83d6-e52e5ea71bbf" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedThreeYears_057e8bb2-0913-498d-a648-d3356ea57abb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedNextTwelveMonths_22ce48c2-146d-43fe-b859-fde9d0dbbe27" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedNextTwelveMonths"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_ce96f4fe-b3cb-43f6-83d6-e52e5ea71bbf" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedNextTwelveMonths_22ce48c2-146d-43fe-b859-fde9d0dbbe27" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedTwoYears_fc08e2ca-79ea-4e9c-a2d8-67704e126e4d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedTwoYears"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_ce96f4fe-b3cb-43f6-83d6-e52e5ea71bbf" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedTwoYears_fc08e2ca-79ea-4e9c-a2d8-67704e126e4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedFiveYears_5f6e166f-4e46-4d88-a182-5ff9eab01871" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedFiveYears"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_ce96f4fe-b3cb-43f6-83d6-e52e5ea71bbf" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedFiveYears_5f6e166f-4e46-4d88-a182-5ff9eab01871" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/DEPOSITSScheduleofCompositionofDepositsDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#DEPOSITSScheduleofCompositionofDepositsDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/DEPOSITSScheduleofCompositionofDepositsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_e9a973c0-b753-43c7-abf2-7fd31aa03ebd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Deposits"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestBearingDepositLiabilities_13b73001-f770-409f-9eb8-07545be9bb04" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestBearingDepositLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_e9a973c0-b753-43c7-abf2-7fd31aa03ebd" xlink:to="loc_us-gaap_NoninterestBearingDepositLiabilities_13b73001-f770-409f-9eb8-07545be9bb04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_InterestBearingTransactionDeposits_4da7049b-1e03-4092-b4b9-7e3d768775ba" xlink:href="buse-20250930.xsd#buse_InterestBearingTransactionDeposits"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_e9a973c0-b753-43c7-abf2-7fd31aa03ebd" xlink:to="loc_buse_InterestBearingTransactionDeposits_4da7049b-1e03-4092-b4b9-7e3d768775ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_DepositsInterestBearingTransactionDepositsSavingDepositsAndMoneyMarketDeposits_72416c35-8bf2-4366-9685-2c122de9b1c5" xlink:href="buse-20250930.xsd#buse_DepositsInterestBearingTransactionDepositsSavingDepositsAndMoneyMarketDeposits"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_e9a973c0-b753-43c7-abf2-7fd31aa03ebd" xlink:to="loc_buse_DepositsInterestBearingTransactionDepositsSavingDepositsAndMoneyMarketDeposits_72416c35-8bf2-4366-9685-2c122de9b1c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDeposits_2b45abb5-6715-4cb2-b31f-0ade361b847c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimeDeposits"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_e9a973c0-b753-43c7-abf2-7fd31aa03ebd" xlink:to="loc_us-gaap_TimeDeposits_2b45abb5-6715-4cb2-b31f-0ade361b847c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/DEPOSITSScheduleofMaturitiesofTimeDepositsDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#DEPOSITSScheduleofMaturitiesofTimeDepositsDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/DEPOSITSScheduleofMaturitiesofTimeDepositsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDeposits_36170a94-c351-4781-bfeb-7cabe0f3cdb0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimeDeposits"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesYearFour_a9ffbd1e-7cf3-4ac8-b6bf-42e487bbe441" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimeDepositMaturitiesYearFour"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_36170a94-c351-4781-bfeb-7cabe0f3cdb0" xlink:to="loc_us-gaap_TimeDepositMaturitiesYearFour_a9ffbd1e-7cf3-4ac8-b6bf-42e487bbe441" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesYearTwo_5582ffe6-60d0-4eec-84ad-fc72dd3e69a6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimeDepositMaturitiesYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_36170a94-c351-4781-bfeb-7cabe0f3cdb0" xlink:to="loc_us-gaap_TimeDepositMaturitiesYearTwo_5582ffe6-60d0-4eec-84ad-fc72dd3e69a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesYearFive_2779961c-170a-488a-8183-abdcdf0117a0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimeDepositMaturitiesYearFive"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_36170a94-c351-4781-bfeb-7cabe0f3cdb0" xlink:to="loc_us-gaap_TimeDepositMaturitiesYearFive_2779961c-170a-488a-8183-abdcdf0117a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesAfterYearFive_530ba6fb-a8ca-42db-8c51-920237a2e658" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimeDepositMaturitiesAfterYearFive"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_36170a94-c351-4781-bfeb-7cabe0f3cdb0" xlink:to="loc_us-gaap_TimeDepositMaturitiesAfterYearFive_530ba6fb-a8ca-42db-8c51-920237a2e658" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesYearOne_8ae7bf70-1caf-4dcf-a2ed-7762303f8529" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimeDepositMaturitiesYearOne"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_36170a94-c351-4781-bfeb-7cabe0f3cdb0" xlink:to="loc_us-gaap_TimeDepositMaturitiesYearOne_8ae7bf70-1caf-4dcf-a2ed-7762303f8529" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesYearThree_5822f39a-3cc3-4466-a69e-621adea6ed79" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimeDepositMaturitiesYearThree"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_36170a94-c351-4781-bfeb-7cabe0f3cdb0" xlink:to="loc_us-gaap_TimeDepositMaturitiesYearThree_5822f39a-3cc3-4466-a69e-621adea6ed79" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesRemainderOfFiscalYear_2498c1da-2856-4188-9f34-8f993302904d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimeDepositMaturitiesRemainderOfFiscalYear"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_36170a94-c351-4781-bfeb-7cabe0f3cdb0" xlink:to="loc_us-gaap_TimeDepositMaturitiesRemainderOfFiscalYear_2498c1da-2856-4188-9f34-8f993302904d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/BORROWINGSScheduleofLongtermBorrowingsDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#BORROWINGSScheduleofLongtermBorrowingsDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/BORROWINGSScheduleofLongtermBorrowingsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_fb02af53-c491-49e9-9921-a833161d07f2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_a797b633-6ab7-47b2-a907-13b85ed66cc4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_fb02af53-c491-49e9-9921-a833161d07f2" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_a797b633-6ab7-47b2-a907-13b85ed66cc4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_fa42613e-ac6b-4a00-aa12-1139a897d987" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_fb02af53-c491-49e9-9921-a833161d07f2" xlink:to="loc_us-gaap_FinanceLeaseLiability_fa42613e-ac6b-4a00-aa12-1139a897d987" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/DERIVATIVEFINANCIALINSTRUMENTSScheduleofInterestIncomeExpenseRecordedonSwapTransactionsDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#DERIVATIVEFINANCIALINSTRUMENTSScheduleofInterestIncomeExpenseRecordedonSwapTransactionsDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/DERIVATIVEFINANCIALINSTRUMENTSScheduleofInterestIncomeExpenseRecordedonSwapTransactionsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_219838d9-c253-4016-b002-4d2113dd0486" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeInterestEarningAssetIncreaseDecrease_7382f760-4bd6-42ba-aab6-3fdd86b3e2f1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeInterestEarningAssetIncreaseDecrease"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_219838d9-c253-4016-b002-4d2113dd0486" xlink:to="loc_us-gaap_InterestIncomeInterestEarningAssetIncreaseDecrease_7382f760-4bd6-42ba-aab6-3fdd86b3e2f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseInterestBearingLiabilityIncreaseDecrease_a7b6a971-c9f6-41ae-bb35-edf6d92fe60d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseInterestBearingLiabilityIncreaseDecrease"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_219838d9-c253-4016-b002-4d2113dd0486" xlink:to="loc_us-gaap_InterestExpenseInterestBearingLiabilityIncreaseDecrease_a7b6a971-c9f6-41ae-bb35-edf6d92fe60d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/DERIVATIVEFINANCIALINSTRUMENTSScheduleofNetGainsLossesRecordedinAOCIDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#DERIVATIVEFINANCIALINSTRUMENTSScheduleofNetGainsLossesRecordedinAOCIDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/DERIVATIVEFINANCIALINSTRUMENTSScheduleofNetGainsLossesRecordedinAOCIDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeExcludedComponentGainLossRecognizedInEarnings_43260939-d6ce-4814-9589-5c7718bb6719" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DerivativeExcludedComponentGainLossRecognizedInEarnings"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_feb25d94-96fb-4fe2-afd8-11b424166242" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeExcludedComponentGainLossRecognizedInEarnings_43260939-d6ce-4814-9589-5c7718bb6719" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_feb25d94-96fb-4fe2-afd8-11b424166242" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_a7533d71-c370-4d65-b1ae-01c0d078d3f8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeExcludedComponentGainLossRecognizedInEarnings_43260939-d6ce-4814-9589-5c7718bb6719" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_a7533d71-c370-4d65-b1ae-01c0d078d3f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationToInterestIncomeBeforeTax_c81ef0d5-72e1-450a-b35c-a8149f692189" xlink:href="buse-20250930.xsd#buse_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationToInterestIncomeBeforeTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeExcludedComponentGainLossRecognizedInEarnings_43260939-d6ce-4814-9589-5c7718bb6719" xlink:to="loc_buse_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationToInterestIncomeBeforeTax_c81ef0d5-72e1-450a-b35c-a8149f692189" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/DERIVATIVEFINANCIALINSTRUMENTSScheduleofInterestRateSwapsRecordedinNoninterestExpenseDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#DERIVATIVEFINANCIALINSTRUMENTSScheduleofInterestRateSwapsRecordedinNoninterestExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/DERIVATIVEFINANCIALINSTRUMENTSScheduleofInterestRateSwapsRecordedinNoninterestExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_c8664ee4-b3ec-44ad-ae76-71ef81d8b734" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DerivativeGainLossOnDerivativeNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_DerivativeGainLossesOnDerivativePayFixedReceiveFloating_4d49cea9-7faa-485c-8f7c-ba0cb93506e2" xlink:href="buse-20250930.xsd#buse_DerivativeGainLossesOnDerivativePayFixedReceiveFloating"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeGainLossOnDerivativeNet_c8664ee4-b3ec-44ad-ae76-71ef81d8b734" xlink:to="loc_buse_DerivativeGainLossesOnDerivativePayFixedReceiveFloating_4d49cea9-7faa-485c-8f7c-ba0cb93506e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_DerivativeGainLossesOnDerivativePayFloatingReceiveFixed_71e14bb0-8c78-4852-95c0-48d2c6bec11f" xlink:href="buse-20250930.xsd#buse_DerivativeGainLossesOnDerivativePayFloatingReceiveFixed"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeGainLossOnDerivativeNet_c8664ee4-b3ec-44ad-ae76-71ef81d8b734" xlink:to="loc_buse_DerivativeGainLossesOnDerivativePayFloatingReceiveFixed_71e14bb0-8c78-4852-95c0-48d2c6bec11f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/EARNINGSPERCOMMONSHAREScheduleofComputationofEarningsPerCommonShareDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#EARNINGSPERCOMMONSHAREScheduleofComputationofEarningsPerCommonShareDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/EARNINGSPERCOMMONSHAREScheduleofComputationofEarningsPerCommonShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_4da675b7-8aa2-4aea-b85b-e9c6ac1ec491" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_30e4304a-9735-4f4c-8063-5d6ec372702e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_4da675b7-8aa2-4aea-b85b-e9c6ac1ec491" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_30e4304a-9735-4f4c-8063-5d6ec372702e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_74be7f65-f3d6-4b85-8694-1b66ea3050fc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_4da675b7-8aa2-4aea-b85b-e9c6ac1ec491" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_74be7f65-f3d6-4b85-8694-1b66ea3050fc" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.busey.com/role/OPERATINGSEGMENTSANDRELATEDINFORMATIONScheduleofFinancialResultsbyOperatingSegmentDetails" xlink:type="simple" xlink:href="buse-20250930.xsd#OPERATINGSEGMENTSANDRELATEDINFORMATIONScheduleofFinancialResultsbyOperatingSegmentDetails"/>
  <link:calculationLink xlink:role="http://www.busey.com/role/OPERATINGSEGMENTSANDRELATEDINFORMATIONScheduleofFinancialResultsbyOperatingSegmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_7e4162e9-e874-4c18-bdcd-780fc9155ada" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_4b815dd1-874b-44a5-a6a0-e7781ad1d7d0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_7e4162e9-e874-4c18-bdcd-780fc9155ada" xlink:to="loc_us-gaap_LaborAndRelatedExpense_4b815dd1-874b-44a5-a6a0-e7781ad1d7d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InformationTechnologyAndDataProcessing_e08e2de3-7eae-4485-a2f8-2aa5e535cd31" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InformationTechnologyAndDataProcessing"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_7e4162e9-e874-4c18-bdcd-780fc9155ada" xlink:to="loc_us-gaap_InformationTechnologyAndDataProcessing_e08e2de3-7eae-4485-a2f8-2aa5e535cd31" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_IntersegmentNoninterestExpense_2807b9bd-df45-4019-99a6-2c564145d1eb" xlink:href="buse-20250930.xsd#buse_IntersegmentNoninterestExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_7e4162e9-e874-4c18-bdcd-780fc9155ada" xlink:to="loc_buse_IntersegmentNoninterestExpense_2807b9bd-df45-4019-99a6-2c564145d1eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_66478261-a2d2-4a93-9bdb-6445ee8e49bb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_7e4162e9-e874-4c18-bdcd-780fc9155ada" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_66478261-a2d2-4a93-9bdb-6445ee8e49bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_OtherNoninterestExpenseAdjusted_7edff41d-a3a0-4ca4-b2bb-11e95d37e724" xlink:href="buse-20250930.xsd#buse_OtherNoninterestExpenseAdjusted"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_7e4162e9-e874-4c18-bdcd-780fc9155ada" xlink:to="loc_buse_OtherNoninterestExpenseAdjusted_7edff41d-a3a0-4ca4-b2bb-11e95d37e724" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_InterchangeExpense_52669d9a-8595-4b95-b189-defaa90fefe6" xlink:href="buse-20250930.xsd#buse_InterchangeExpense"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_7e4162e9-e874-4c18-bdcd-780fc9155ada" xlink:to="loc_buse_InterchangeExpense_52669d9a-8595-4b95-b189-defaa90fefe6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_30029c5a-11a3-46ad-9054-e2c2a62a0ee2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_buse_IntersegmentNoninterestIncome_505453fe-fbae-4bc1-a54a-6aa9c38a6cff" xlink:href="buse-20250930.xsd#buse_IntersegmentNoninterestIncome"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_30029c5a-11a3-46ad-9054-e2c2a62a0ee2" xlink:to="loc_buse_IntersegmentNoninterestIncome_505453fe-fbae-4bc1-a54a-6aa9c38a6cff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_1250dd49-f93a-4e20-aed8-8213031a780f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_30029c5a-11a3-46ad-9054-e2c2a62a0ee2" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_1250dd49-f93a-4e20-aed8-8213031a780f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncomeOther_fdcad649-fe8d-4236-9b28-6a8b20beed2e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestIncomeOther"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_30029c5a-11a3-46ad-9054-e2c2a62a0ee2" xlink:to="loc_us-gaap_NoninterestIncomeOther_fdcad649-fe8d-4236-9b28-6a8b20beed2e" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
