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                          March 5, 2021

       Van A. Dukeman
       Chief Executive Officer
       First Busey Corporation
       100 W. University Ave
       Champaign, IL 61820

                                                        Re: First Busey
Corporation
                                                            Registration
Statement on Form S-4
                                                            Filed February 26,
2021
                                                            File No. 333-253608

       Dear Mr. Dukeman:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Tonya K.
Aldave at (202) 551-3601 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Finance
       cc:                                              Jennifer Durham King,
Esq.